Evidence map›Paper›PMID 31205418›Full record

ArticleMicrobiology insights2019

Haloacid Dehalogenase Proteins: Novel Mediators of Metabolic Plasticity in

Philip M Frasse, Audrey R Odom John

Open access · goldAbstract readComment
In one paragraph

Article in Microbiology insights, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Philip M FrasseDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.ORCID https://orcid.org/0000-0002-5529-3280
Audrey R Odom JohnDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.ORCID https://orcid.org/0000-0001-8395-8537
Washington University in St. Louis · US

Funding

TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
Training Program in Cellular and Molecular BiologyT32GM139774 · NIGMS · WASHINGTON UNIVERSITY · PI HEATHER L TRUE-KROB · 2021 to 2026
$6.7M
MEP pathway resistance in Plasmodium falciparumR01AI103280 · NIAID · WASHINGTON UNIVERSITY · PI Audrey Ragan Odom John · 2013 to 2026
$5.5M
Inhibition of MEP pathway Isoprenoid BiosynthesisR01AI123433 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI DOWD, CYNTHIA SCHIECK, MEYERS, MARVIN J · 2016 to 2020
$2.6M
Towards noninvasive diagnosis of malariaR21AI144472 · NIAID · WASHINGTON UNIVERSITY · PI ODOM JOHN, AUDREY RAGAN · 2019 to 2020
$485k
NIAID NIH HHS R01 AI103280NIAID NIH HHS R01 AI123433NIAID NIH HHS R21 AI144472NIGMS NIH HHS T32 GM007067NIGMS NIH HHS T32 GM139774
6 · The paper itself

Abstract

Widespread antimalarial drug resistance has prompted the need for new therapeutics and greater understanding of malaria parasite biology. To this end, the isoprenoid biosynthesis inhibitor fosmidomycin has been used to probe the metabolic regulation in the malaria parasite,

Indexed as

Cof-like hydrolaseglycolysisHADhaloacid dehalogenaseisoprenoid biosynthesismalariametabolic regulationmetabolismmethylerythritol phosphate pathwayPlasmodium

Identifiers

PMID31205418
PMCPMC6537242
OpenAlexW2945428525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.