ReviewThe Pediatric infectious disease journal2019
Viral Bacterial Interactions in Children: Impact on Clinical Outcomes.
Review in The Pediatric infectious disease journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Early-life respiratory syncytial virus infection and asthma.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Viral-bacterial codetection and clinical and laboratory characteristics in children hospitalized with lower respiratory tract infections in a private hospital in Lima, Peru: a cross-sectional study.Tropical diseases, travel medicine and vaccines · 2026Article
- COVID-19 and Influenza Deaths in Australian Children 2018-2023: A National Case Analysis.Journal of the Pediatric Infectious Diseases Society · 2025Article
- Cavitary Lesions and Pleural Effusion: A Case of Necrotizing Pneumonia in a Young Child.Cureus · 2025Article
- Multiomics as instrument to promote 3P medical approaches for the overall management of respiratory syncytial viral infections.The EPMA journal · 2025Review
- Increased risk of bacterial pneumonia before and after respiratory syncytial virus infection in young children.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Impact of Viral Lower Respiratory Tract Infection (LRTI) in Early Childhood (0-2 Years) on Lung Growth and Development and Lifelong Trajectories of Pulmonary Health: A National Institutes of Health (NIH) Workshop Summary.Pediatric pulmonology · 2025Review
- Case Report: Pediatric respiratory viral infection failure: a case series of eight fatalities in children under 5 years old in Iran.Frontiers in pediatrics · 2025Article
- Respiratory Syncytial Virus Risk Profile in Hospitalized Infants and Comparison with Influenza and COVID-19 Controls in Valladolid, Spain, 2010-2022.Infectious diseases and therapy · 2024Article
- Multicenter study to describe viral etiologies, clinical profiles, and outcomes of hospitalized children with severe acute respiratory infections, Egypt 2022.Scientific reports · 2023Article
- Influence of Sex on Respiratory Syncytial Virus Genotype Infection Frequency and Nasopharyngeal Microbiome.Journal of virology · 2023Article
- Risk factors and incidence of invasive bacterial infection in severe bronchiolitis: the RICOIB prospective study.BMC pediatrics · 2022Article
- Respiratory viruses associated with severe mechanically ventilated pneumonia in children.Journal of medical virology · 2022Article
- Early Microbial-Immune Interactions and Innate Immune Training of the Respiratory System during Health and Disease.Children (Basel, Switzerland) · 2021Review
- When two for the price of one isn't a bargain: estimating prevalence and microbiology of bacterial co-infections in patients with COVID-19.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020Article
- Time to Say Goodbye to Bronchiolitis, Viral Wheeze, Reactive Airways Disease, Wheeze Bronchitis and All That.Frontiers in pediatrics · 2020Review
- Immune Dysregulation in Children With Down Syndrome.Frontiers in pediatrics · 2020Review
- COVID-19: Why does disease severity vary among individuals?Respiratory medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Respiratory viral infections are associated with significant morbidity and mortality in children < 5 years of age worldwide. Among all respiratory viruses, respiratory syncytial virus (RSV) is the world's leading cause of bronchiolitis and pneumonia in young children. There are known populations at risk for severe disease but the majority of children who require hospitalization for RSV infection are previously healthy. Viral and host factors have been associated with the pathogenesis of RSV disease; however, the mechanisms that explain the wide variability in the clinical presentation are not completely understood. Recent studies suggest that the complex interaction between the respiratory microbiome, the host's immune response and the virus may have an impact on the pathogenesis and severity of RSV infection. In this review, we summarize the current evidence regarding the epidemiologic link, the mechanisms of viral-bacterial interactions, and the associations between the upper respiratory tract microbiome and RSV disease severity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.