Evidence map›Paper›PMID 31205212›Full record

ArticleThe journal of trauma and acute care surgery2019

An inflammatory pulmonary insult post-traumatic brain injury worsens subsequent spatial learning and neurological outcomes.

Christina L Jacovides, Syed Ahmed, Yujin Suto, Andrew J Paris, Ryan Leone, Jordan McCarry, Melpo Christofidou-Solomidou, Lewis J Kaplan, Douglas H Smith, Daniel N Holena and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of trauma and acute care surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Christina L JacovidesFrom the Division of Traumatology, Surgical Critical Care and Emergency Surgery (C.L.J., S.A., R.L., J.M., L.J.K., D.N.H., C.W.S., J.L.P.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Emergency and Critical Care Medicine (Y.S.), Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan; Department of Medicine (A.J.P.), University of Pennsylvania, Philadelphia, PA; Department of Medicine, Pulmonary, Allergy and Critical Care Division (M.C-S.), University of Pennsylvania, Philadelphia, Pennsylvania; and Center for Brain Injury and Repair, Department of Neurosurgery (D.H.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Syed Ahmed
Yujin Suto
Andrew J Paris
Ryan Leone
Jordan McCarry
Melpo Christofidou-Solomidou
Lewis J Kaplan
Douglas H Smith
Daniel N Holena
C William Schwab
Jose L Pascual
University of Pennsylvania · USTokyo Medical University Hachioji Medical Center · JP

Funding

Detection and Mechanisms of Mild Traumatic Brain InjuryR01NS092398 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SMITH, DOUGLAS HAMILTON · 2015 to 2019
$1.9M
NINDS NIH HHS R01 NS092398
6 · The paper itself

Abstract

backgroundSevere traumatic brain injury (TBI) patients are at high risk for early aspiration and pneumonia. How pneumonia impacts neurological recovery after TBI is not well characterized. We hypothesized that, independent of the cerebral injury, pneumonia after TBI delays and worsens neurological recovery and cognitive outcomes.

methodsFifteen CD1 male mice were randomized to sham craniotomy or severe TBI (controlled cortical impact [CCI] - velocity 6 m/s, depth 1.0 mm) ± intratracheal lipopolysaccharide (LPS-2 mg/kg in 0.1 mL saline) as a pneumonia bioeffector. Neurological functional recovery by Garcia Neurologic Testing (GNT) and body weight loss were recorded daily for 14 days. On Days 6-14, animals underwent Morris Water Maze learning and memory testing with cued trials (platform visible), spatial learning trials (platform invisible, spatial cues present), and probe (memory) trials (platform removed, spatial clues present). Intergroup differences were assessed by the Kruskal-Wallis test with Bonferroni correction (p < 0.05).

resultsWeight loss was greatest in the CCI + LPS group (maximum 24% on Day 3 vs. 8% [Sham], 7% [CCI], both on Day 1). GNT was lowest in CCI + LPS during the first week. Morris Water Maze testing demonstrated greater spatial learning impairment in the CCI + LPS group vs. Sham or CCI counterparts. Cued learning and long-term memory were worse in CCI + LPS and CCI as compared to Sham.

conclusionA pneumonia bioeffector insult after TBI worsens weight loss and mortality in a rodent model. Not only is spatial learning impaired, but animals are more debilitated and have worse neurologic performance. Understanding the adverse effects of pneumonia on TBI recovery is the first step d patients.

Indexed as

Spatial LearningAnimalsBrain Injuries, TraumaticDisease Models, AnimalLipopolysaccharidesMaleMaze LearningMemoryMemory DisordersMicePneumoniaWeight LossLipopolysaccharides

Identifiers

PMID31205212
PMCPMC10497189
OpenAlexW2952918195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.