Evidence map›Paper›PMID 31204706›Full record

ArticleJournal of genetics2019

Genetic variant rs10937405 of TP63 and susceptibility to lung cancer risk in north Indian population.

G H Rasool Bhat, Amrita Bhat, Sonali Verma, Itty Sethi, Ruchi Shah, Varun Sharma, S Minerva, Divya Bakshi, Bhanu Sharma, Sandeep Koul and 3 more

Abstract read
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In one paragraph

Article in Journal of genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Polymorphism in theAfrican health sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

G H Rasool BhatCancer Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra 182 320, India. kumar.rakesh@smvdu.ac.in.
Amrita Bhat
Sonali Verma
Itty Sethi
Ruchi Shah
Varun Sharma
S Minerva
Divya Bakshi
Bhanu Sharma
Sandeep Koul
Deepak Abrol
Audesh Bhat
Rakesh Kumar
Shri Mata Vaishno Devi University · INCentral University of Jammu · INGovernment Medical College · INUniversity of Jammu · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies including genomewide association studies (GWASs) in diverse ethnic populations have reported a significant association of genetic variant rs10937405 of TP63 with nonsmall cell lung cancer (NSCLC). However, no data are available from any Indian population on the association of this variant with NSCLC. Using TaqMan genotyping chemistry, we conducted a case-control study involving 190 NSCLC cases and 400 ethnic, age-matched controls to explore the association of rs10937405 genetic variant with NSCLC in patients from north India. Our data support that the rs10937405 variant is also significantly associated with the NSCLC and is a risk factor in the north Indian populations to develop NSCLC. However, unlike most other studies, the wild-type allele T appears to be the risk allele, as its frequency was significantly higher in the cases than controls (0.439 in cases versus 0.383 in controls. OR=1.95 (1.23-3.09 at 95% CI);

Indexed as

AllelesGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyAgedCase-Control StudiesFemaleGenotypeHumansIndiaLung NeoplasmsMaleMiddle AgedTranscription FactorsTumor Suppressor ProteinsTP63 protein, humanTranscription FactorsTumor Suppressor Proteins

Identifiers

PMID31204706
OpenAlexW2948930091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.