Evidence map›Paper›PMID 31204705›Full record

ArticleJournal of genetics2019

Minor alleles of genetic variants in second heart field increase the risk of hypoplastic right heart syndrome.

Enshi Wang, Yu Nie, Xuesong Fan, Zhe Zheng, Haiyong Gu, Hao Zhang, Shengshou Hu

Abstract read
PubMed
In one paragraph

Article in Journal of genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Enshi WangDepartment of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, People's Republic of China. shengshouh@sina.cn.
Yu Nie
Xuesong Fan
Zhe Zheng
Haiyong Gu
Hao Zhang
Shengshou Hu
Chinese Academy of Medical Sciences & Peking Union Medical College · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoplastic right heart syndrome(HRHS) is characterized by hypoplastic right ventricle (RV); Numerous transcriptional cascades in the second heart field (SHF) regulate RVdevelopment. The relationship of SHF gene variants with human HRHS remains unknown. The whole lengths of 17 SHF genes were sequenced in 16 HRHS, and the selected single-nucleotide variants (SNVs) were then genotyped in HRHS, other congenital heart disease (CHD) and healthy control. Luciferase assay was performed to verify the effect of

Indexed as

AllelesGenetic Association StudiesGenetic Predisposition to DiseaseGenetic VariationBiomarkersEchocardiographyElectrocardiographyEnhancer Elements, GeneticForkhead Transcription FactorsGenetic TestingGenotypeHeart Defects, CongenitalHumansOdds RatioPolymerase Chain ReactionPolymorphism, Single NucleotideBiomarkersForkhead Transcription Factorsmesenchyme fork head 1 proteinT-Box Domain ProteinsTBX20 protein, human

Identifiers

PMID31204705
OpenAlexW2944803305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.