Evidence map›Paper›PMID 31204557›Full record

ArticleAutophagy2020

Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling.

Yong Lin, Chunchen Wu, Xueyu Wang, Shi Liu, Kaitao Zhao, Thekla Kemper, Haisheng Yu, Mengqi Li, Jiming Zhang, Mingzhou Chen and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Autophagy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. The Roles of Alix and VPS4A in Autophagy and Endosomal Pathways and Their Relation to HBV Replication.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  5. Article
  6. Article
  7. Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases.Journal of Zhejiang University. Science. B · 2025
    Review
  8. Article
  9. Review
  10. Epigenetic addition of mCell death & disease · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Exosome-Autophagy Crosstalk in Enveloped Virus Infection.International journal of molecular sciences · 2023
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Autophagy as a dual-faced host response to viral infections.Frontiers in cellular and infection microbiology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Yong LinInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0001-9171-0195
Chunchen WuState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Science, Wuhan, China.
Xueyu WangInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Shi LiuState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
Kaitao ZhaoState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Science, Wuhan, China.
Thekla KemperInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Haisheng YuState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
Mengqi LiState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
Jiming ZhangDepartment of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
Mingzhou ChenState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
Ying ZhuState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
Xinwen ChenState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Science, Wuhan, China.
Mengji LuInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Wuhan University · CNUniversity of Duisburg-Essen · DEWuhan Institute of Virology · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucosamine (GlcN), a dietary supplement widely utilized to promote joint health and effective in the treatment of osteoarthritis, is an effective macroautophagy/autophagy activator

Indexed as

Signal TransductionAnimalsAutophagyDisease Models, AnimalEnterovirusGene Expression RegulationGlucosamineHepatitis B Surface AntigensHepatitis B virusHep G2 CellsHumansHydrodynamicsInfluenza A virusLiverLysosomesMaleGlucosamineHepatitis B Surface AntigensMechanistic Target of Rapamycin Complex 1AutophagyglucosamineHBVlysosomal acidificationMTORC1 signaling

Identifiers

PMID31204557
PMCPMC6999643
OpenAlexW2949804722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.