Evidence map›Paper›PMID 31204500›Full record

ArticleCell transplantation2019

MicroRNA-101a Regulates Autophagy Phenomenon via the MAPK Pathway to Modulate Alzheimer's-Associated Pathogenesis.

Qian Li, Yu Wang, Wenjie Peng, Yanjie Jia, Jinhua Tang, Wanwei Li, John H Zhang, Jun Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. MicroRNAs in neurodegenerative diseases: from molecular mechanisms to clinical biomarkers, detection methods and therapeutic strategies-advances and challenges.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  19. The Potential Role of miRNA-Regulated Autophagy in Alzheimer's Disease.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Qian Li1 Department of Pediatrics, Daping Hospital, Army Medical University, Chongqing, China.
Yu Wang2 Department of Outpatient, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wenjie Peng3 Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yanjie Jia4 Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Jinhua Tang3 Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wanwei Li1 Department of Pediatrics, Daping Hospital, Army Medical University, Chongqing, China.
John H Zhang5 Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.ORCID 0000-0002-4319-4285
Jun Yang3 Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0003-2487-0417
The Affiliated Yongchuan Hospital of Chongqing Medical University · CNArmy Medical University · CNFirst Affiliated Hospital of Zhengzhou University · CNLoma Linda University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a type of neurodegenerative disorder and the most common form of dementia. MicroRNA (miRNA) has been shown to play a role in various diseases, including AD. It also has been reported to regulate autophagy. We extracted miRNA from blood samples and constructed an miRNA-101a lentivirus vector. In this study we found the level of miRNA-101a was significantly reduced in the plasma of patients with AD and APPswe/PS1ΔE9 transgenic mice. The relative expression of miRNA-101a exhibited a relatively high diagnostic performance (area under receiver operating characteristic curve: 0.8725) in the prediction of AD with a sensitivity of 0.913 and a specificity of 0.733 at the threshold of 0.6463. Under electron microscopy, autophagic vacuoles in AD-related cells numbered more than the cells up-regulating miRNA-101a in the in vitro experiments. Dual-luciferase reporter assay and Western blot results proved that the MAPK1 pathway plays a role in the formation of autophagic vacuoles in AD. This study found that the autophagy phenomenon regulated by miRNA-101a via the MAPK pathway might be a new mechanism in AD. This could provide new insights into AD formation and treatment.

Indexed as

AutophagyMAP Kinase Signaling SystemAgedAlzheimer DiseaseAnimalsBrainCase-Control StudiesCell Line, TumorFemaleGene Expression RegulationHumansMaleMice, TransgenicMicroRNAsModels, BiologicalMicroRNAsMIRN101 microRNA, humanAlzheimer’s diseaseautophagyMAPK1MicroRNA-101a

Identifiers

PMID31204500
PMCPMC6728707
OpenAlexW2950992807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.