SynthesisCartilage2021
The Value of SPECT/CT for Knee Osteoarthritis: A Systematic Review.
Synthesis in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The DC/TMD Conundrum.Clinical oral investigations · 2026Review
- Time- and dose-related pathological changes in knee osteoarthritis rat model induced by monosodium iodoacetate.Animal models and experimental medicine · 2026Article
- Recent evolution in imaging techniques for assessment of synovitis in osteoarthritis.Skeletal radiology · 2025Review
- Osteoarthritis: Mechanisms and Therapeutic Advances.MedComm · 2025Review
- Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review.Osteoarthritis and cartilage open · 2025Review
- Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside.Aging and disease · 2024Review
- Knee osteoarthritis: Current status and research progress in treatment (Review).Experimental and therapeutic medicine · 2023Review
- Cutting-Edge Approaches in Arthroplasty: Before, during and after Surgery.Journal of personalized medicine · 2022Article
- AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis.International journal of molecular sciences · 2022Article
- Computed Tomography Image Segmentation Algorithm to Detect the Curative Effect of Radial Shock Wave Therapy for Knee Osteoarthritis.Journal of healthcare engineering · 2021Article
- Knee Osteoarthritis-Current Diagnosis and Treatment Options-A Narrative Review.Current health sciences journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSingle photon emission computed tomography (SPECT/CT) is a diagnostic option for knee osteoarthritis patients without osteoarthritic features on X-ray; however, the added value of SPECT/CT remains debatable in the diagnostic algorithm.
objectiveTo review the added value of SPECT/CT in the diagnostic algorithm of knee osteoarthritis. STUDY
designSystematic review.
methodsA systematic search was carried out in the databases EMBASE, MEDLINE, and the Cochrane collaboration. The retrieved articles were screened for relevance on title and abstract. This was followed by a full-text study quality appraisal of the remaining articles. Finally, a total of 9 trials were included.
resultsThe use of SPECT/CT might objectify some clinical knee osteoarthritis symptoms. It could correlate with findings on plain radiography and magnetic resonance imaging. Furthermore, there is some evidence SPECT/CT gives additional information compared with these imaging modalities; however, superiority is not proven. The uptake on SPECT could predict the intraoperative macroscopic findings. Yet the clinical relevance remains unclear.
conclusionThere is no strong evidence SPECT/CT should play a role in the diagnosing and decision-making processes of knee osteoarthritis. Yet there is evidence suggesting SPECT/CT might give additional information in the diagnosing process. More research would be of added value to answer this research question.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.