Trial reportProgress in orthodontics2019
Comparative evaluation of Icon® resin infiltration and Clinpro™ XT varnish on colour and fluorescence changes of white spot lesions: a randomized controlled trial.
Trial report in Progress in orthodontics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Laboratory Evaluation of Icon® Resin Infiltration and Vanish™ XT Varnish, on Color Changes of White Spot Lesions
Effect of Bioactive Glass Versus Resin Infiltration (ICON) on the Depth of White Spot Lesions: An in Vitro Study
Who cites it
31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Outcomes of resin infiltration for white spot lesions at different time points: a systematic review and meta-analysis.European journal of orthodontics · 2026Pooled it
- Efficacy of various interventions for the management of white spot lesions associated with fixed orthodontic treatment: a systematic review and network meta-analysis of randomized controlled trials.BMC oral health · 2026Pooled it
- Comparison of therapies of white spot lesions: a systematic review and network meta-analysis.BMC oral health · 2023Pooled it
- Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the Application of Infiltrative Resins: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Efficacy of resin infiltration to mask post-orthodontic or non-post-orthodontic white spot lesions or fluorosis - a systematic review and meta-analysis.Clinical oral investigations · 2021Pooled it
- Comparative assessment of four treatments for post orthodontic white spot lesions over a 24-month period: a randomized controlled clinical trial.BMC oral health · 2026Trial
- In-vitro and in-vivo comparative studies of treatment effects on enamel demineralization during orthodontic therapy: implications for clinical early-intervention strategy.Clinical oral investigations · 2024Trial
- Comparative evaluation of four treatments for postorthodontic white spot lesions: a randomized controlled trial.Clinical oral investigations · 2023Trial
- Modulating the Optical Properties of Initial Caries Lesions Through Low-Viscosity Resin Infiltration: A Spectrophotometric Evaluation.Journal of functional biomaterials · 2026Article
- Comparative clinical evaluation of Icon resin infiltration and Vanish XT varnish for managing white spot lesions: a randomized controlled trial.The Saudi dental journal · 2026Article
- Comparing the Aesthetic Outcomes of Orthodontically Induced White Spot Lesion Using Icon® Resin Infiltration, Fluoride Varnish and Micro-Abrasion: A Pilot Study.Journal of pharmacy & bioallied sciences · 2025Article
- Color Change and Color Stability of White Spot Lesions Treated with Resin Infiltration, Microabrasion, or Nano-Hydroxyapatite Remineralization: An In Vitro Study.Dentistry journal · 2025Article
- What are the global trends in research on resin infiltration in dentistry? An altmetric and bibliometric analysis.Brazilian oral research · 2025Article
- The Impact of Pre-Treatment with Desensitizing Agents on the Effectiveness of In-Office Bleaching: An In Vitro Study.Materials (Basel, Switzerland) · 2024Article
- Effect of sodium hypochlorite and EDTA pretreatment on the resin infiltration efficacy and acid resistance of enamel white spot lesions: an in vitro study.BMC oral health · 2024Article
- A Review of White Spot Lesions: Development and Treatment with Resin Infiltration.Dentistry journal · 2024Review
- Effect of the use of remineralization agents before resin infiltration on the treatment of initial enamel lesions: an in-vitro study.BMC oral health · 2024Article
- White Spot Lesions in Fixed Orthodontics: A Literature Review on Etiology, Prevention, and Treatment.Cureus · 2024Review
- Aesthetic impact of resin infiltration and its mechanical effect on ceramic bonding for white spot lesions.BMC oral health · 2024Article
- Orthodontic aligners: between passion and science.Dental press journal of orthodontics · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this trial was to comparatively evaluate Icon® resin infiltration and Clinpro™ XT varnish in restoring aesthetics of white spot lesions (WSLs) present post-orthodontic treatment. MATERIALS AND
methodsTwo hundred forty WSLs were detected in 193 teeth of 12 patients. The participants were analysed-before intervention (T
resultsImmediately after the intervention, Icon® resin infiltration showed statistically significant better improvement than Clinpro™ XT varnish in restoring the colour (p = 0.000); however, at 3 (p = 0.001) and 6 months (p = 0.000), this was reversed. Except at 3 months, the fluorescence loss sequentially reduced more for Icon® resin infiltration (4.48 ± 1.42 at T
conclusionsClinpro™ XT varnish showed significantly better improvement than Icon® resin infiltration in restoring the colour and lightness of the WSLs at 3 and 6 months. The fluorescence loss significantly recovered with both intervention methods between immediate application and at 6 months. However, Clinpro™ XT varnish-treated WSLs showed a statistically significant difference compared to the adjacent sound enamel at 6 months.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.