Evidence map›Paper›PMID 31204425›Full record

ArticleChemical communications (Cambridge, England)2019

Oriented attachment of V

João C F Nogueira, Michelle K Greene, Daniel A Richards, Alexander O Furby, John Steven, Andrew Porter, Caroline Barelle, Christopher J Scott, Vijay Chudasama

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

João C F NogueiraDepartment of Chemistry, University College London, London, UK. v.chudasama@ucl.ac.uk.
Michelle K Greene
Daniel A Richards
Alexander O Furby
John Steven
Andrew Porter
Caroline Barelle
Christopher J Scott
Vijay Chudasama

Funding

Medical Research Council MC_PC_15013
6 · The paper itself

Abstract

Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.

Indexed as

Drug Delivery SystemsHumansMolecular StructureNanoparticlesPolyestersPolyethylene GlycolsReceptors, AntigenPolyesterspolyethylene glycol-poly(lactide-co-glycolide)Polyethylene GlycolsReceptors, Antigen

Identifiers

PMID31204425
PMCPMC6873773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.