ArticleCell metabolism2019
Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice.
Open access · bronzeAbstract read
In one paragraph
Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 256 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
256citing papers in PubMed, 1 pooled it
16.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
256 citing papers in PubMed, 1 synthesis or guideline pooled it, 403 citations in OpenAlex.
- A systematic review and meta-analysis of the SIRT1 response to exercise.Scientific reports · 2023Pooled it
- Sublingual NMN administration increases early circulating terminal catabolites 2PY and 4PY compared with oral administration in healthy adult men.Scientific reports · 2026Trial
- Circulating Metabolites Treat Human TMJ-OA by Eliminating Senescent Chondrocytes via the C1QBP/C1q/p14ARF Axis.Journal of extracellular vesicles · 2026Trial
- A Mechanism-Based Framework for Anti-Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell-Based Interventions.Aging cell · 2026Review
- Article
- Nicotinamide Mononucleotide Adenylyltransferase 1 and NADMetabolites · 2026Review
- Circulating extracellular vesicles in plasma carry accessible molecular signatures of aging in mice.bioRxiv : the preprint server for biology · 2026Article
- Muscle-derived Mimecan regulates hypothalamus-brown adipose tissue communication and promotes health and lifespan in mice.Cell metabolism · 2026Article
- Engineering Extracellular Vesicles for Anti-Aging Therapy: Mechanisms, Applications, and Perspectives.Aging cell · 2026Review
- Article
- Multicellular senescence programs in the aged heart.Journal of molecular and cellular cardiology plus · 2026Review
- An integrated anti-aging framework targeting NADRedox biology · 2026Review
- Article
- Senescent cells in systemic aging: SASP heterogeneity, immune escape, and endocrine modulation.Biogerontology · 2026Review
- Exosome-Delivered eNAMPT From Exercise Activates SIRT1 to Counteract Age-Related Hepatic Steatosis and Fibrosis.Aging cell · 2026Article
- METTL1-deficient mesenchymal stem cells protect against metabolic-associated fatty liver disease by increasing NAMPT secretion.Stem cells translational medicine · 2026Article
- Aging reduces motivation through decreased Bdnf expression in the ventral tegmental area.Molecular psychiatry · 2026Article
- Possible Involvement of NAMPT in the Anti-Obesity Effect of Oral Administration of Fermented Rice withInternational journal of molecular sciences · 2026Article
- FGF2 Enhances MSCs Secretome Therapy for Skin Photoaging by Delaying Senescence via iNAMPT/AMPK Signaling and Facilitating eNAMPT-Mediated Regenerative Crosstalk.Stem cell reviews and reports · 2026Article
- Circulating eNAMPT in Glaucoma: A Semi-Quantitative Plasma Analysis Before and After Nicotinamide Supplementation.Translational vision science & technology · 2026Article
196 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Mitsukuni YoshidaDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; MD-PhD Program, Washington University School of Medicine, St. Louis, MO 63110, USA.
Akiko SatohSleep and Aging Research Regulation Project Team, National Center for Geriatrics and Gerontology, Aichi, Japan.
Jonathan B LinDepartment of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; MD-PhD Program, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kathryn F MillsDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yo SasakiDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Nicholas RensingDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michael WongDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Rajendra S ApteDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shin-Ichiro ImaiDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Gerontology, Laboratory of Molecular Life Science, Institute of Biomedical Research and Innovation, Kobe, Japan. Electronic address: imaishin@wustl.edu.
Washington University in St. Louis · USNational Center for Geriatrics and Gerontology · JP
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MNATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1MWASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Philip Raymond Williams · 1985 to 2026
$18.4MWashington University Institute of Clinical and Translational Sciences (TL1)TL1TR002344 · NCATS · WASHINGTON UNIVERSITY · PI Jay F. Piccirillo · 2017 to 2026
$8.5MWashington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2015 to 2019
$7.1MTHE IMPORTANCE OF MACROPHAGE SENESCENCE IN REGULATING ANGIOGENESIS IN THE EYER01EY019287 · NEI · WASHINGTON UNIVERSITY · PI APTE, RAJENDRA S · 2010 to 2021
$3.9MENAMPT-MEDIATED ADIPO-HYPOTHALAMIC COMMUNICATION FOR NAD+ PRODUCTION AND AGINGR01AG047902 · NIA · WASHINGTON UNIVERSITY · PI IMAI, SHIN-ICHIRO · 2014 to 2023
$3.2MTHE ROLE OF DORSOMEDIAL HYPOTHALAMIC NEURONS IN MAMMALIAN AGING AND LONGEVITYR01AG037457 · NIA · WASHINGTON UNIVERSITY · PI IMAI, SHIN-ICHIRO · 2011 to 2020
$3.1MANIMAL SUPPORT SPACE FOR NEUROSCIENCEC06RR015502 · NCRR · WASHINGTON UNIVERSITY · PI CICERO, THEODORE J · 2000 to 2000
$2.0MNCATS NIH HHS TL1 TR002344NCATS NIH HHS UL1 TR002345NCRR NIH HHS C06 RR015502NEI NIH HHS P30 EY002687NEI NIH HHS R01 EY019287NIA NIH HHS R01 AG037457NIA NIH HHS R01 AG047902NICHD NIH HHS U54 HD087011NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIGMS NIH HHS T32 GM007200
Abstract
Aging is a significant risk factor for impaired tissue functions and chronic diseases. Age-associated decline in systemic NAD
Indexed as
AgingLongevityAdultAgedAged, 80 and overAnimalsCells, CulturedCytokinesExtracellular VesiclesHEK293 CellsHumansMaleMiceMice, Inbred C57BLMice, TransgenicMiddle AgedCytokinesNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanadipose tissueagingeNAMPTEVexosomeextracellular vesiclehypothalamuslongevitymetabolismNAD+
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.