ArticleCell metabolism2019
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.
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Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 95 papers.
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95citing papers in PubMed
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95 citing papers in PubMed, 139 citations in OpenAlex.
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- Inhibition of Microglial TRPV1 Ameliorates Brain Injury After Intracerebral Hemorrhage by Suppressing AMPK/PINK1-Mediated Mitophagy.CNS neuroscience & therapeutics · 2026Article
- Fructose-1,6-bisphosphate couples glycolytic activity to cell adhesion.Nature cell biology · 2026Article
- Autophagy in the liver.Autophagy reports · 2026Review
- A metabolic switch for myelination.Cell regeneration (London, England) · 2025Article
- Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction.Autophagy · 2025Article
- Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages.Cell research · 2025Article
- Neuronal differentiation regulator CEND1 coordinately suppresses tumor growth and energetics via AMPK signaling in brain glioma.Cell & bioscience · 2025Article
- Sweet signals for myelin: glucose sensing redirected to regeneration.Nature metabolism · 2025Article
- Oligodendrocyte precursor cell-specific blocking of low-glucose-induced activation of AMPK ensures myelination and remyelination.Nature metabolism · 2025Article
- ATG16L1 controls mammalian vacuolar proton ATPase.The Journal of cell biology · 2025Article
- Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy.Journal of advanced research · 2025Article
- Intracellular CaBiologia futura · 2025Review
- Bioenergetics and metabolism of the pulmonary endothelium. Scientific session I: ReSPIRE 2025.American journal of physiology. Lung cellular and molecular physiology · 2025Review
- V-ATPase and Lysosomal Energy Sensing in Periodontitis and Medicine-Related Osteonecrosis of the Jaw.Biomolecules · 2025Review
- The Emerging Roles of Metabolic Reprogramming in Non-Small Cell Lung Cancer Progression.Frontiers in bioscience (Landmark edition) · 2025Review
- Muscle-specific AXIN1 and AXIN2 double knockout does not alter AMPK/mTORC1 signalling or glucose metabolism.The Journal of physiology · 2025Article
- Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
31 authors at 8 institutions in 3 countries.
Mengqi LiState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Chen-Song ZhangState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Yue ZongState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Jin-Wei FengState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Teng MaState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Meiqin HuState Key Laboratory of Membrane Biology, Institute of Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, 100871 Beijing, China.
Zhizhong LinState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Xiaotong LiState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Changchuan XieState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Yaying WuState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Dong JiangState Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Ying LiState Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Cixiong ZhangState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Xiao TianState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Wen WangCAS Key Laboratory of Separation Science for Analytical Chemistry, Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, China.
Yanyan YangState Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, 100871 Beijing, China.
Jie ChenState Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, 100871 Beijing, China.
Jiwen CuiState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Yu-Qing WuState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Xin ChenState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Qing-Feng LiuState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Jianfeng WuState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Shu-Yong LinState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Zhiyun YeState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China.
Ying LiuState Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, 100871 Beijing, China.
Hai-Long PiaoCAS Key Laboratory of Separation Science for Analytical Chemistry, Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, China.
Li YuState Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Zhuan ZhouState Key Laboratory of Membrane Biology, Institute of Molecular Medicine, PKU-IDG/McGovern Institute for Brain Research, Peking University, 100871 Beijing, China.
Xiao-Song XieMcDermott Center of Human Growth and Development MC8591, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
D Grahame HardieDivision of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.
Sheng-Cai LinState Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102 Fujian, China. Electronic address: linsc@xmu.edu.cn.
Xiamen University · CNPeking University · CNTsinghua University · CNCenter for Life Sciences · CNChinese Academy of Sciences · CNDalian Institute of Chemical Physics · CNThe University of Texas Southwestern Medical Center · USUniversity of Dundee · GB
Funding
Wellcome Trust 204766/Z/16/Z
Abstract
Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear. Here, we show that FBP-unoccupied aldolase interacts with and inhibits endoplasmic reticulum (ER)-localized transient receptor potential channel subfamily V, inhibiting calcium release in low glucose. The decrease of calcium at contact sites between ER and lysosome renders the inhibited TRPV accessible to bind the lysosomal v-ATPase that then recruits AXIN:LKB1 to activate AMPK independently of AMP. Genetic depletion of TRPVs blocks glucose starvation-induced AMPK activation in cells and liver of mice, and in nematodes, indicative of physical requirement of TRPVs. Pharmacological inhibition of TRPVs activates AMPK and elevates NAD
Indexed as
AcrylamidesAdenosine TriphosphatasesAMP-Activated Protein KinasesAnimalsBridged Bicyclo Compounds, HeterocyclicCaenorhabditis elegansCalciumCalcium ChannelsEndoplasmic ReticulumEnzyme ActivationFructose-Bisphosphate AldolaseGene Knockout TechniquesGlucoseHEK293 CellsHumansLysosomes3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamideAcrylamidesAdenosine TriphosphatasesAMP-Activated Protein KinasesBridged Bicyclo Compounds, HeterocyclicCalciumCalcium ChannelsFructose-Bisphosphate AldolaseGlucoseTRPV Cation ChannelsaldolaseAMP-activated protein kinaseAMPKglucose sensingtransient receptor potential channelsTRPVv-ATPase
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