ArticleDevelopmental cell2019
Mechanical Function of the Nucleus in Force Generation during Epithelial Morphogenesis.
Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 75 citations in OpenAlex.
- Chromatin remodelling: a driving force in reverse mechanotransduction.RNA biology · 2026Review
- Three-dimensional mechanical cooperativity optimises epithelial wound healing.The EMBO journal · 2026Article
- Mechanical cues enhance chondrocyte function: Insights from mechanoreception, regulation, and biological responses.Mechanobiology in medicine · 2025Review
- A role for Myosin in triggering and executing amnioserosa cell delaminations during dorsal closure.Scientific reports · 2025Article
- Coordinated active repression operates via transcription factor cooperativity and multiple inactive promoter states in a developing organism.Nature communications · 2025Article
- Elimination of cells with local mismatch in differentiation timing contributes to synchronize tissue development.iScience · 2025Article
- Basal Cell-Contact Dynamics Influence Tissue Packing in a Proliferating Mammalian Epithelium.bioRxiv : the preprint server for biology · 2025Article
- Nuclear position controls the activity of cortical actomyosin networks powering simultaneous morphogenetic events.Nature communications · 2025Article
- The transmembrane protein Syndecan is required for stem cell survival and maintenance of their nuclear properties.PLoS genetics · 2025Article
- Tensions on the actin cytoskeleton and apical cell junctions in thebioRxiv : the preprint server for biology · 2024Article
- β-H-Spectrin is a key component of an apical-medial hub of proteins during cell wedging in tube morphogenesis.Journal of cell science · 2024Article
- Mechanical stress combines with planar polarised patterning during metaphase to orient embryonic epithelial cell divisions.Development (Cambridge, England) · 2024Article
- Tensions on the actin cytoskeleton and apical cell junctions in theFrontiers in cell and developmental biology · 2024Article
- Epithelial apoptotic pattern emerges from global and local regulation by cell apical area.Current biology : CB · 2023Article
- Dissecting morphogenetic apoptosis through a genetic screen in Drosophila.Life science alliance · 2023Article
- Systematic analysis of RhoGEF/GAP localizations uncovers regulators of mechanosensing and junction formation during epithelial cell division.Current biology : CB · 2023Article
- The Elephant in the Cell: Nuclear Mechanics and Mechanobiology.Journal of biomechanical engineering · 2022Review
- Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network.Biomolecules · 2022Review
- Shielding of actin by the endoplasmic reticulum impacts nuclear positioning.Nature communications · 2022Article
- Force-generating apoptotic cells orchestrate avian neural tube bending.Developmental cell · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanical forces are critical regulators of cell shape changes and developmental morphogenetic processes. Forces generated along the epithelium apico-basal cell axis have recently emerged as essential for tissue remodeling in three dimensions. Yet the cellular machinery underlying those orthogonal forces remains poorly described. We found that during Drosophila leg folding cells eventually committed to die produce apico-basal forces through the formation of a dynamic actomyosin contractile tether connecting the apical surface to a basally relocalized nucleus. We show that the nucleus is anchored to basal adhesions by a basal F-actin network and constitutes an essential component of the force-producing machinery. Finally, we demonstrate force transmission to the apical surface and the basal nucleus by laser ablation. Thus, this work reveals that the nucleus, in addition to its role in genome protection, actively participates in mechanical force production and connects the contractile actomyosin cytoskeleton to basal adhesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.