Evidence map›Paper›PMID 31204103›Full record

ArticleCell2019

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.

Daniel G W Alanine, Doris Quinkert, Rasika Kumarasingha, Shahid Mehmood, Francesca R Donnellan, Nana K Minkah, Bernadeta Dadonaite, Ababacar Diouf, Francis Galaway, Sarah E Silk and 22 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 169 citations in OpenAlex.

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  16. Overview of the host immune response toJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors at 6 institutions in 4 countries.

Daniel G W AlanineThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
Doris QuinkertThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Rasika KumarasinghaBurnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia.
Shahid MehmoodDepartment of Chemistry, University of Oxford, Oxford OX1 3QZ, UK.
Francesca R DonnellanThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Nana K MinkahCenter for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Ave. N., #500, Seattle, WA 98109, USA.
Bernadeta DadonaiteThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Ababacar DioufLaboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA.
Francis GalawayCell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
Sarah E SilkThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Abhishek JamwalDepartment of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
Jennifer M MarshallThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Kazutoyo MiuraLaboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA.
Lander FoquetCenter for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Ave. N., #500, Seattle, WA 98109, USA.
Sean C EliasThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Geneviève M LabbéThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Alexander D DouglasThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Jing JinThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Ruth O PayneThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Joseph J IllingworthThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
David J PattinsonThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
David PulidoThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Barnabas G WilliamsThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Willem A de JonghExpreS(2)ion Biotechnologies, SCION-DTU Science Park, Agern Allé 1, Hørsholm 2970, Denmark.
Gavin J WrightCell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
Stefan H I KappeCenter for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Ave. N., #500, Seattle, WA 98109, USA.
Carol V RobinsonDepartment of Chemistry, University of Oxford, Oxford OX1 3QZ, UK.
Carole A LongLaboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA.
Brendan S CrabbBurnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia.
Paul R GilsonBurnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia.
Matthew K HigginsDepartment of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address: matthew.higgins@bioch.ox.ac.uk.
Simon J DraperThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK. Electronic address: simon.draper@ndm.ox.ac.uk.
Jenner Institute · GBUniversity of Oxford · GBBurnet Institute · AUVector Oncology (United States) · USWellcome Sanger Institute · GBExpreS2ion Biotechnologies (Denmark) · DK

Funding

Host Immune Responses to Antigens of Malaria ParasitesZIAAI001020 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LONG, CAROLE · 2009 to 2025
$13.6M
Medical Research Council MR/K017632/1Medical Research Council MR/K025554/1Medical Research Council MR/N013468/1Medical Research Council MR/N020413/1Wellcome Trust 101020/Z/13/ZWellcome Trust 104923/Z/14/ZWellcome Trust 105399/Z/14/ZWellcome Trust 106917/Z/15/ZWellcome Trust 201477/Z/16/ZWellcome Trust 206194
6 · The paper itself

Abstract

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against the disease-causing blood-stage of malaria. However, little is known about how human antibodies confer functional immunity against this antigen. We isolated a panel of human monoclonal antibodies (mAbs) against PfRH5 from peripheral blood B cells from vaccinees in the first clinical trial of a PfRH5-based vaccine. We identified a subset of mAbs with neutralizing activity that bind to three distinct sites and another subset of mAbs that are non-functional, or even antagonistic to neutralizing antibodies. We also identify the epitope of a novel group of non-neutralizing antibodies that significantly reduce the speed of red blood cell invasion by the merozoite, thereby potentiating the effect of all neutralizing PfRH5 antibodies as well as synergizing with antibodies targeting other malaria invasion proteins. Our results provide a roadmap for structure-guided vaccine development to maximize antibody efficacy against blood-stage malaria.

Indexed as

AdolescentAdultAnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ProtozoanBinding SitesCarrier ProteinsCross ReactionsEpitopesErythrocytesFemaleHealthy VolunteersHEK293 CellsHumansMalaria, FalciparumAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ProtozoanCarrier ProteinsEpitopesMalaria VaccinesProtozoan ProteinsRH5 protein, Plasmodium falciparumblood-stagelive-cell microscopymalariamerozoitemonoclonal antibodyneutralizationRH5structural vaccinologysynergyX-ray crystallography

Identifiers

PMID31204103
PMCPMC6602525
OpenAlexW2952823957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.