Evidence map›Paper›PMID 31204102›Full record

ArticleCell2019

Fc Glycan-Mediated Regulation of Placental Antibody Transfer.

Madeleine F Jennewein, Ilona Goldfarb, Sepideh Dolatshahi, Cormac Cosgrove, Francesca J Noelette, Marina Krykbaeva, Jishnu Das, Aniruddh Sarkar, Matthew J Gorman, Stephanie Fischinger and 13 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05856396 (Maternal Determinants of Infant Immunity to Pertussis), which is not on this map. Cited by 149 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 3 pooled it
20.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05856396 phase4completednot on this mapstarted 2023, after this paper: background citation

Maternal Determinants of Infant Immunity to Pertussis

TypeinterventionalSponsorCentre Hospitalier Universitaire Saint PierreRan2023 to 2025Enrolled200ConditionsVaccination, Infection, Maternal-Fetal Relations, PertussisArmsTriaxis® (Pertussis-containing vaccine), Vaxelis® (Pertussis-containing vaccine)
3 · Its place in the literature

Who cites it

149 citing papers in PubMed, 3 syntheses or guidelines pooled it, 209 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Differences in Pneumococcal andFrontiers in immunology · 2021
    Trial
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Immune development in early life.Nature immunology · 2026
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 2 countries.

Madeleine F JenneweinRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Ilona GoldfarbObstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA.
Sepideh DolatshahiRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cormac CosgroveRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Francesca J NoeletteRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Marina KrykbaevaRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Jishnu DasRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Aniruddh SarkarRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Matthew J GormanRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Stephanie FischingerRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Carolyn M BoudreauRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Joelle BrownGastroenterology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Jennifer H CooperriderGastroenterology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Jasneet AnejaGastroenterology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Todd J SuscovichRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Barney S GrahamVaccine Research Center, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA.
Georg M LauerGastroenterology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Tessa GoetghebuerDepartment of Pediatrics, Hôpital Saint-Pierre, Brussels 1000, Belgium.
Arnaud MarchantInstitute for Medical Immunology, Université Libre de Bruxelles, Charleroi 6041, Belgium.
Douglas LauffenburgerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; MIT Center for Gynepathology Research, Cambridge, MA 02139, USA.
Arthur Y KimDivision of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA.
Laura E RileyDepartment of Obstetrics and Gynecology, New York Presbyterian/Weill Cornell Medical Center, New York, NY 10065, USA. Electronic address: lar9110@med.cornell.edu.
Galit AlterRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address: galter@mgh.harvard.edu.
Ragon Institute of MGH, MIT and Harvard · USMassachusetts General Hospital · USMassachusetts Institute of Technology · USCentre Hospitalier Universitaire de Saint-Pierre · BENational Institute of Allergy and Infectious Diseases · USPresbyterian Hospital · USUniversité Libre de Bruxelles · BE

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Demystifying the antiviral activity of the IgG3+ antibody responseR37AI080289 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ALTER, GALIT · 2015 to 2022
$5.8M
Demystifying the antiviral activity of the IgG3+ antibody responseR01AI080289 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI JUELG, BORIS DOMINIK · 2009 to 2024
$4.1M
Optimization of Broadly Neutralizing Antibodies for HIV EradicationR01AI129797 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H. · 2017 to 2021
$3.6M
Tuning Fc-effector functions of HIV-specific antibodiesR01AI102660 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ALTER, GALIT · 2012 to 2015
$3.0M
NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI080289NIAID NIH HHS R01 AI102660NIAID NIH HHS R01 AI129797NIAID NIH HHS R37 AI080289
6 · The paper itself

Abstract

Despite the worldwide success of vaccination, newborns remain vulnerable to infections. While neonatal vaccination has been hampered by maternal antibody-mediated dampening of immune responses, enhanced regulatory and tolerogenic mechanisms, and immune system immaturity, maternal pre-natal immunization aims to boost neonatal immunity via antibody transfer to the fetus. However, emerging data suggest that antibodies are not transferred equally across the placenta. To understand this, we used systems serology to define Fc features associated with antibody transfer. The Fc-profile of neonatal and maternal antibodies differed, skewed toward natural killer (NK) cell-activating antibodies. This selective transfer was linked to digalactosylated Fc-glycans that selectively bind FcRn and FCGR3A, resulting in transfer of antibodies able to efficiently leverage innate immune cells present at birth. Given emerging data that vaccination may direct antibody glycosylation, our study provides insights for the development of next-generation maternal vaccines designed to elicit antibodies that will most effectively aid neonates.

Indexed as

AdolescentAdultBelgiumCell DegranulationCohort StudiesFemaleGlycosylationHistocompatibility Antigens Class IHumansImmunoglobulin GInfant, NewbornKiller Cells, NaturalLymphocyte ActivationMalePlacentaPolysaccharidesFCGR3A protein, humanFc receptor, neonatalHistocompatibility Antigens Class IImmunoglobulin GPolysaccharidesReceptors, FcReceptors, IgGADCCantibody functionalityantibody glycosylationmaternal vaccinationneonatal immunologytrans-placental transfer

Identifiers

PMID31204102
PMCPMC6741440
OpenAlexW2950802088

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.