ArticleMolecular biology reports2019
Role of ashwagandha methanolic extract in the regulation of thyroid profile in hypothyroidism modeled rats.
Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera).Phytotherapy research : PTR · 2026Review
- Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review.Phytotherapy research : PTR · 2026Review
- Alternative and Complementary Therapies: A Review Exploring the Role of Yoga and Ayurveda-based Herbal Medicines in Alleviating Hypothyroidism and Its Neuropsychiatric Manifestations.Annals of neurosciences · 2026Review
- Article
- The Clinical Implications of Ashwagandha (Nutrients · 2026Review
- Ameliorative effect of ferulic acid on thyroid dysfunction against propyl-thiouracil induced hypothyroid rats.Endocrine · 2024Article
- Eltroxin and Hesperidin mitigate testicular and renal damage in hypothyroid rats: amelioration of oxidative stress through PPARγ and Nrf2/HO-1 signaling pathway.Laboratory animal research · 2024Article
- Can Ashwagandha Benefit the Endocrine System?-A Review.International journal of molecular sciences · 2023Review
- Recent Advancements in Extraction Techniques of Ashwagandha (ACS omega · 2023Review
- Article
- AshwagandhaPharmaceutics · 2023Review
- Antihypothyroid Effect of Salidroside.Molecules (Basel, Switzerland) · 2022Article
- Review
- The protective effect of hesperidin on the liver of hypothyroid rats mediated by nuclear factor erythroid 2-related factor 2-dependent activation of heme oxygenase 1.Journal of molecular histology · 2022Article
- Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats.Oxidative medicine and cellular longevity · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the anti-hypothyroidism potential of ashwagandha methanolic extract (AME). This target was performed through induction of animal model of hypothyroidism by propylthiouracil. After 1 month from treatments, blood samples were collected for biochemical determinations, and liver and kidney were removed for the determination of oxidative stress markers and thyroid gland was removed for histopathological examination. The total phenolic compounds in the extract and the in vitro radical scavenging activity of extract were also determined. The results revealed that the induction of hypothyroidism by propylthiouracil induced a significant increase in serum TSH level but it induced significant decreases in the levels of total T3, free T3, free T4, and total T4 hormones compared with the control values. Also, serum glucose, Il-6, and body weight gain increased significantly while Il-10 and blood hemoglobin levels showed significant decrease. Induction of hypothyroidism increased also the levels of hepatic and renal MDA and NO and decreased significantly the values of GSH, GPx and Na
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