Evidence map›Paper›PMID 31203460›Full record

ArticleMedical oncology (Northwood, London, England)2019

A study of mechanistic mapping of novel SNPs to male breast cancer.

Raman Preet Kaur, Vicky Kumar, Gowhar Shafi, Rajesh Vashistha, Mahesh Kulharia, Anjana Munshi

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Male Breast Cancer: Current Scenario and Future Perspectives.Technology in cancer research & treatment
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Raman Preet KaurDepartment of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151001, India.
Vicky KumarDepartment of Computational Sciences, Central University of Punjab, Bathinda, 151001, India.
Gowhar ShafiDepartment of Clinical Genomics and Bioinformatics, Positive Bioscience, Mumbai, India.
Rajesh VashisthaMax Super-specialty Hospital, Bathinda, 151001, India.
Mahesh KulhariaDepartment of Computational Sciences, Central University of Punjab, Bathinda, 151001, India. kulharia@gmail.com.
Anjana MunshiDepartment of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151001, India. anjanadurani@yahoo.co.in.ORCID http://orcid.org/0000-0002-7657-8592
Central University of Punjab · INMax Super Speciality Hospital · IN

Funding

Central University of Punjab Department grant
6 · The paper itself

Abstract

Alterations in BRCA2, PALB2, CHEK2, and p53 genes have been identified for their association with male breast cancer in various studies. The incidence of male breast cancer in India is consistent with its global rate. The present study was carried out with an aim to evaluate the genetic alterations in male breast cancer patients from Malwa region of Punjab, India. Four male breast cancer patients belonging to different families were recruited from Guru Gobind Singh Medical College and Hospital, Faridkot, India. A total of 51 genes reported with implications in the pathogenesis of breast cancer were screened using next generation sequencing. Germline variations were found in BRCA1, BRCA2, PMS2, p53, and PALB2 genes, previously reported to be associated with MBC as well as FBC. In addition to these, 13 novel missense alterations were detected in eight genes including STK11, FZR1, PALB2, BRCA2, NF2, BAP1, BARD1, and CHEK2. Impact of these missense alterations on structure and function of protein was also analyzed through molecular dynamics simulation. Structural analysis of these single nucleotide polymorphisms (SNPs) revealed significant impact on the encoded protein functioning.

Indexed as

AgedAMP-Activated Protein Kinase KinasesBRCA2 ProteinBreast Neoplasms, MaleCheckpoint Kinase 2Fanconi Anemia Complementation Group N ProteinHumansIndiaMaleMiddle AgedMolecular Dynamics SimulationMutationPedigreePolymorphism, Single NucleotideProtein Serine-Threonine KinasesTumor Suppressor Protein p53AMP-Activated Protein Kinase KinasesBRAP protein, humanBRCA2 ProteinBRCA2 protein, humanCheckpoint Kinase 2CHEK2 protein, humanFanconi Anemia Complementation Group N ProteinPALB2 protein, humanProtein Serine-Threonine KinasesSTK11 protein, humanTP53 protein, humanTumor Suppressor Protein p53Ubiquitin-Protein LigasesGermline variationsMale breast cancerMolecular dynamics simulationNovel missense alterationsSNPs

Identifiers

PMID31203460
OpenAlexW2950517833

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.