Evidence map›Paper›PMID 31202970›Full record

ArticleUltrasonics2019

Sonothrombolysis with magnetic microbubbles under a rotational magnetic field.

Bohua Zhang, Howuk Kim, Huaiyu Wu, Yu Gao, Xiaoning Jiang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Advances in nanomaterial-based targeted drug delivery systems.Frontiers in bioengineering and biotechnology · 2023
    Review
  5. Magnetic Nanoparticles Mediated Thrombolysis-A Review.IEEE open journal of nanotechnology · 2023
    Article
  6. Ultrasound-Guided Intravascular Sonothrombolysis With a Dual Mode Ultrasound Catheter: In Vitro Study.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022
    Article
  7. Article
  8. Article
  9. Dual-Frequency Intravascular Sonothrombolysis: An In Vitro Study.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. AnJournal of medical ultrasound
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Bohua ZhangDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh 27695, NC, USA.
Howuk KimDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh 27695, NC, USA.
Huaiyu WuDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh 27695, NC, USA.
Yu GaoInstitute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, China.
Xiaoning JiangDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh 27695, NC, USA. Electronic address: xjiang5@ncsu.edu.
North Carolina State University · USNanjing University of Posts and Telecommunications · CN

Funding

Integrated Dual-frequency Ultrasound Catheter for Accelerated Sonothrombolysis (iDUCAS)R01HL141967 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Xiaoning Jiang, Zhen Xu · 2018 to 2026
$4.1M
NHLBI NIH HHS R01 HL141967
6 · The paper itself

Abstract

Thrombosis is an extremely critical clinical condition where a clot forms inside a blood vessel which blocks the blood flow through the cardiovascular system. Previous sonothrombolysis methods using ultrasound and microbubbles (MBs) often have a relatively low lysis rate due to the low microbubbles concentration at clot region caused by blood flow in the vessel. To solve this problem, the magnetic microbubbles (MMBs) that can be retained by an outer magnetic field against blood flow are used in this study. Here we report the development of a new method using the rotational magnetic field to trap and vibrate magnetic microbubbles at target clot region and then using an intravascular forward-looking ultrasound transducer to activate them acoustically. In this study, we investigated the influence of different blood flow conditions, vessel occlusion conditions (partial and fully occluded), clot ages (fresh, retracted), ultrasound parameters (input voltage, duty cycle) and rotational magnetic field parameters (amplitude, frequency) on the thrombolysis rate. The results showed that the additional use of magnetic microbubbles significantly enhances in vitro lysis of blood clot.

Indexed as

CavitationMagnetic microbubblesMagnetic nanoparticleSonothrombolysisThrombolysis

Identifiers

PMID31202970
PMCPMC6710138
OpenAlexW2950320881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.