ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2019
Seroprevalence of hepatitis B virus: Findings from a population-based household survey in KwaZulu-Natal, South Africa.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 35 citations in OpenAlex.
- Prevalence and risk factors of hepatitis B, hepatitis C, and syphilis among reproductive-age adults in the Tigray region, Northern Ethiopia: a community-based cross-sectional study.Scientific reports · 2026Article
- Sexually transmitted infection prevalence and Neisseria gonorrhoeae antimicrobial resistance patterns in men who have sex with men with or without urethral discharge syndrome in Johannesburg, South Africa, 2024.PLOS global public health · 2026Article
- Hepatitis B seroprevalence among HIV-positive adults in the Free State, South Africa.Southern African journal of HIV medicine · 2025Article
- Antenatal Screening for Hepatitis B Virus in Uganda: Missed Opportunities for Diagnosis and Treatment.Open forum infectious diseases · 2024Article
- MicroRNA levels in patients with chronic hepatitis B virus and HIV coinfection in a high-prevalence setting; KwaZulu-Natal, South Africa.BMC infectious diseases · 2024Article
- Hepatitis B Virus Prevalence among HIV-Uninfected People Living in Rural and Peri-Urban Areas in Botswana.Microorganisms · 2024Article
- A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024Article
- Hepatitis B Viral Infection and its Associated Factors among Population Aged at Least 15 Years in Three Selected Cities of Burundi.The East African health research journal · 2024Article
- Hepatitis B Virus Prevalence and Mother-to-Child Transmission Risk in an HIV Early Intervention Cohort in KwaZulu-Natal, South Africa.Open forum infectious diseases · 2023Article
- Hepatitis B Immunization Status in Children with Chronic Kidney Disease: Experience at a Single Center, Egypt.Journal of clinical medicine · 2023Article
- Hepatitis B Virus Immunity Gap: A Six-Year Laboratory Data Review of Hepatitis B Serological Profiles in Gauteng Province, South Africa.Advances in virology · 2023Article
- High Prevalence of Hepatitis B Virus Infection Among People With HIV in Rural and Periurban Communities in Botswana.Open forum infectious diseases · 2023Article
- Hepatitis B Vaccination Impact and the Unmet Need for Antiviral Treatment in Blantyre, Malawi.The Journal of infectious diseases · 2022Article
- Low prevalence of hepatitis B virus infection in HIV-uninfected pregnant women in Cape Town, South Africa: implications for oral pre-exposure prophylaxis roll out.BMC infectious diseases · 2022Article
- Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants.Journal of leukocyte biology · 2021Article
- Hepatitis B virus infection and hepatocellular carcinoma in sub-Saharan Africa: Implications for elimination of viral hepatitis by 2030?World journal of gastroenterology · 2021Review
- Hepatitis B, hepatitis C and HIV prevalence and related sexual and substance use risk practices among key populations who access HIV prevention, treatment and related services in South Africa: findings from a seven-city cross-sectional survey (2017).BMC infectious diseases · 2020Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHepatitis B virus (HBV) infection is a major cause of morbidity and mortality; however, little is known about the prevalence and distribution of HBV in some populations and regions.
methodsA total of 9791 participants, 15-49 years old, were enrolled in a household survey in KwaZulu-Natal, South Africa. Peripheral blood samples were tested for markers of HBV (hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), antibody to HBeAg (anti-HBe)) and analysed, accounting for multilevel sampling and weighted to represent the population.
resultsOverall HBsAg prevalence was 4.0% (95% confidence interval (CI) 3.4-4.5%): 4.8% (95% CI 3.8-5.8%) in men and 3.2% (95% CI 2.5-3.9%) in women (p=0.01). Among HBsAg-positive participants, 35.2% (95% CI 29.2-41.2%) were HBeAg-positive and 66.3% (95% CI 60.1-72.4%) were anti-HBe-positive. HBsAg prevalence was 6.4% (95% CI 5.3-7.5%) among HIV-positive participants compared to 2.6% (95% CI 1.9-3.2%) among HIV-negative participants (p<0.01), and was higher among HIV-positive men (8.7%, 95% CI 6.3-11.2%) than among HIV-positive women (5.0%, 95% CI 3.8-6.2%) (p<0.01).
conclusionsHBV infection among HIV-positive men remains an important public health problem in communities in KwaZulu-Natal, South Africa. The prevalence of HBsAg and HBeAg highlight the importance of surveillance and an important missed opportunity for the scale-up of programmes to achieve the goal of controlling HBV for public health benefit.
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