ReviewJACC. Cardiovascular imaging2020
Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction: Understanding Mechanisms by Using Noninvasive Methods.
Review in JACC. Cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
159 citing papers in PubMed, 289 citations in OpenAlex.
- A First-in-Human Study of Ulacamten, a Novel Cardiac Myosin Inhibitor for HFpEF.Clinical pharmacokinetics · 2026Trial
- Left Atrial Volume Index and Left Ventricular Mass Index Determine the Benefits of Spironolactone in Patients With Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2026Trial
- Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction.The American journal of cardiology · 2022Trial
- Mitral annular calcification severity and invasive hemodynamic confirmation of HFpEF: A prospective observational study.Medicine · 2026Observational
- Effects of sympathomodulation on pulse wave properties in heart failure with preserved ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Ocular microvascular alterations in patients with heart failure with preserved ejection fraction.Japanese journal of ophthalmology · 2026Observational
- Chemotherapy-Induced Right Ventricular Dysfunction.Medicina (Kaunas, Lithuania) · 2026Review
- Cardiac fibroblast diversity in HFpEF: states, niches, interorgan drivers and targets.Nature reviews. Cardiology · 2026Review
- Clinical translation and engineering challenges of soft robotic cardiac sleeves for heart failure.Nature communications · 2026Review
- Preserved and reduced ejection fraction manifest as two unique phenotypes of diastolic dysfunction-a mechanistic study.European heart journal. Imaging methods and practice · 2026Article
- Acoustic Cardiography Captures Stress-Dependent Ventricular Dysfunction and Distinguishes Heart Failure Phenotypes in a Porcine Model.Biomedicines · 2026Article
- Understanding HFpEF Through Imaging: Strengths, Limitations, and Current State of the Art.JACC. Cardiovascular imaging · 2026Review
- Magel2 deficiency promotes cardiac remodeling and increases arrhythmogenic susceptibility in a mouse model relevant to Prader-Willi and Schaaf-Yang syndromes.Clinical science (London, England : 1979) · 2026Article
- The Gut-Heart Axis: A Microbiome-Centered Perspective on Heart Failure.International journal of molecular sciences · 2026Review
- [Heart failure with preserved ejection fraction in old age : Diagnostic strategies in clinical practice].Zeitschrift fur Gerontologie und Geriatrie · 2026Article
- Echocardiographic assessment in arterial hypertension: a contemporary narrative review.Echo research and practice · 2026Review
- Metabolic syndrome predicts cardiovascular and all-cause adverse outcomes in patients with chronic inflammatory arthritis.Clinical rheumatology · 2026Observational
- Echocardiographic evaluation and clinical implications of cardiac remodeling in obesity.Journal of echocardiography · 2026Review
- Alterations in left atrial volume and function after atrial fibrillation ablation evaluated by three-dimensional speckle-tracking echocardiography.Scientific reports · 2026Article
- Anemia and Prognosis in Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.Cureus · 2026Review
99 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Research in the last decade has substantially advanced our understanding of the pathophysiology of heart failure with preserved ejection fraction (HFpEF). However, treatment options remain limited as clinical trials have largely failed to identify effective therapies. Part of this failure may be related to mechanistic heterogeneity. It is speculated that categorizing HFpEF patients based upon underlying pathophysiological phenotypes may represent the key next step in delivering the right therapies to the right patients. Echocardiography may provide valuable insight into both the pathophysiology and underlying phenotypes in HFpEF. Echocardiography also plays a key role in the evaluation of patients with unexplained dyspnea, where HFpEF is suspected but the diagnosis remains unknown. The combination of the E/e' ratio and right ventricular systolic pressure has recently been shown to add independent value to the diagnostic evaluation of patients suspected of having HFpEF. Finally, echocardiography enables identification of the different causes that mimic HFpEF but are treated differently, such as valvular heart disease, pericardial constriction, and high-output heart failure or infiltrative myopathies such as cardiac amyloid. This review summarizes the current understanding of the pathophysiology and phenotyping of HFpEF with particular attention to the role of echocardiography in this context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.