Evidence map›Paper›PMID 31202719›Full record

ArticleJournal of infection and public health

Dynamic changes of lymphocyte counts in adult patients with severe pandemic H1N1 influenza A.

Yandong Cheng, Hong Zhao, Peixin Song, Zhaoping Zhang, Junhao Chen, Yi-Hua Zhou

Open access · goldAbstract read
In one paragraph

Article in Journal of infection and public health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Regulatory CD4Journal of leukocyte biology · 2021
    Trial
  4. Clinical Characteristics and Cytokines of Children With Lower Respiratory Tract Infection Caused by Influenza A After COVID-19.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
  5. Afebrile Presentation in COPD Patients with Influenza A: A Risk Factor for Prolonged Viral Shedding.International journal of chronic obstructive pulmonary disease · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yandong ChengDepartment of Internal Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.
Hong ZhaoDepartment of Infectious Diseases, The Second Hospital of Nanjing, Nanjing 210003, China.
Peixin SongDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.
Zhaoping ZhangDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.
Junhao ChenDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China. Electronic address: nj_cjh@aliyun.com.
Yi-Hua ZhouDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China; Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China; Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing 210008, China. Electronic address: zgr03summer@126.com.
Nanjing Drum Tower Hospital · CNNanjing Second Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLymphopenia has been observed in severe pandemic influenza A/H1N1 in developed countries. However, data from developing countries are rare and dynamic change of lymphocyte counts in severe pandemic influenza A/H1N1 is scarcely reported. This study aimed to observe change of lymphocyte counts in patients with severe pandemic influenza A/H1N1 and to investigate the correlation of lymphopenia and severe pandemic influenza A/H1N1.

methodsWe retrospectively analyzed the white blood cell counts and differentials and other clinical data in 21 hospitalized patients with severe pandemic influenza A/H1N1 confirmed by reverse-transcription PCR during 2009 and 2010.

resultsAll patients, except two cases with bacterial co-infections, had normal or reduced white blood cell counts. Seventeen (81.0%) patients had decreased lymphocyte proportions (<20%) and counts (<0.8×10

conclusionsLymphopenia along with other clinical parameters may be helpful in early differential diagnosis of severe pandemic influenza A/H1N1.

Indexed as

Lymphocyte CountAdolescentAdultAgedAged, 80 and overFemaleHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanLymphocytesLymphopeniaMaleMiddle AgedRetrospective StudiesYoung AdultLymphopeniaPneumoniaSevere pandemic influenza A/H1N1Virus

Identifiers

PMID31202719
PMCPMC7102863
OpenAlexW2952958102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.