ArticleNeuron2019
Prefrontal Cortex Regulates Sensory Filtering through a Basal Ganglia-to-Thalamus Pathway.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.
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Who cites it
100 citing papers in PubMed, 1 synthesis or guideline pooled it, 212 citations in OpenAlex.
- Brain Gray Matter Alterations in Hepatic Encephalopathy: A Voxel-Based Meta-Analysis of Whole-Brain Studies.Frontiers in human neuroscience · 2022Pooled it
- The Role of Expectations and Endogenous Opioids in Mindfulness-Based Relief of Experimentally Induced Acute Pain.Psychosomatic medicineTrial
- Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons.iScience · 2026Article
- Article
- Heterogeneous Medial Prefrontal Cortex Ensembles Exhibit Reproducible Internal Temporal Dynamics during Choice Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Utility of Tablet-Based Eye Tracking for Early Screening of Poststroke Cognitive Impairment: Diagnostic Cohort Study.JMIR mHealth and uHealth · 2026Article
- Cognitive functions of the GPe.Trends in neurosciences · 2026Review
- Electrical Coupling within Thalamocortical Networks Cumulatively Reduces Cortical Correlation to Sensory Inputs.eNeuro · 2026Article
- Orbitofrontal cortex drives predictive filtering of sensory responses.Nature neuroscience · 2026Article
- Cortical functional hierarchy disruption following subcortical stroke.BMC medicine · 2026Article
- Thalamic reticular neurons provide cell type-specific modulation of sound processing in the auditory thalamus.PLoS biology · 2026Article
- Selective attention to auditory and visual modalities converges onto noncholinergic basal forebrain neurons.Science advances · 2026Article
- Activation of the Gamma-Aminobutyric Acid (GABA)ergic Neural Circuit in Salicylate-Induced Tinnitus: the Inferior Colliculus to the Medial Geniculate Body.Clinical and experimental otorhinolaryngology · 2026Article
- TMEM16A ablation in cholinergic medial habenula neurons induces early-onset schizophrenia-like phenotypes in mice.Molecular brain · 2026Article
- Attentional modulation of multisensory integration across the cortical hierarchy.Frontiers in neural circuits · 2026Review
- Concurrent changes in psychological distress and pain thresholds following brief mindfulness: an exploratory phenotyping study of chronic pain.Frontiers in psychology · 2026Article
- A neuropsychological perspective on sensory hypersensitivity after acquired brain injury.Brain communications · 2026Review
- Filtering the noise: a cerebellar-centered framework for understanding and treating mental illness -a paradigm shift in psychiatry.Frontiers in psychiatry · 2026Article
- Cognitive training shapes brain plasticity and schematic representations.Behavioral and brain functions : BBF · 2025Review
- The neural basis for uncertainty processing in hierarchical decision making.Nature communications · 2025Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
To make adaptive decisions, organisms must appropriately filter sensory inputs, augmenting relevant signals and suppressing noise. The prefrontal cortex (PFC) partly implements this process by regulating thalamic activity through modality-specific thalamic reticular nucleus (TRN) subnetworks. However, because the PFC does not directly project to sensory TRN subnetworks, the circuitry underlying this process had been unknown. Here, using anatomical tracing, functional manipulations, and optical identification of PFC projection neurons, we find that the PFC regulates sensory thalamic activity through a basal ganglia (BG) pathway. Engagement of this PFC-BG-thalamus pathway enables selection between vision and audition by primarily suppressing the distracting modality. This pathway also enhances sensory discrimination and is used for goal-directed background noise suppression. Overall, our results identify a new pathway for attentional filtering and reveal its multiple roles in sensory processing on the basis of internal goals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.