ArticleNeuroImage2019
Association between the oral microbiome and brain resting state connectivity in smokers.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review exploring the association between the human gut microbiota and brain connectivity in health and disease.Molecular psychiatry · 2023Pooled it
- Examining the Influence of the Human Gut Microbiota on Cognition and Stress: A Systematic Review of the Literature.Nutrients · 2022Pooled it
- The gut microbiome is associated with brain structure and function in schizophrenia.Scientific reports · 2021Trial
- Influence of heat-non-burn tobacco aerosol on the microbiome of biofilm from human whole saliva bacteria in vitro.Clinical oral investigations · 2026Article
- Large-scale classification of metagenomic samples: a comparative analysis of classical machine learning techniques vs a novel brain-inspired hyperdimensional computing approach.bioRxiv : the preprint server for biology · 2025Article
- Alterations of the nasal and oral microbiota in multiple sclerosis.EBioMedicine · 2025Article
- Oral microbiota and central nervous system diseases: A review.Neuroprotection (Chichester, England) · 2025Review
- Characterization of the salivary microbiome in healthy individuals under fatigue status.Frontiers in cellular and infection microbiology · 2025Article
- The Oral-Gut-Brain Axis: The Influence of Microbes as a Link of Periodontitis With Ischemic Stroke.CNS neuroscience & therapeutics · 2024Review
- Bacteriome and mycobiome dysbiosis in oral mucosal dysplasia and oral cancer.Periodontology 2000 · 2024Review
- The adolescent and young adult microbiome and its association with substance use: a scoping review.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Effect of different forms of tobacco on the oral microbiome in healthy adults: a systematic review.Frontiers in oral health · 2024Review
- Impact of the gut microbiome on nicotine's motivational effects and glial cells in the ventral tegmental area in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies.Chemical reviews · 2023Review
- Beneficial modulation of human health in the oral cavity and beyond using bacteriocin-like inhibitory substance-producing streptococcal probiotics.Frontiers in microbiology · 2023Review
- New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer.Nutrients · 2022Review
- The role of the oral microbiome in smoking-related cardiovascular risk: a review of the literature exploring mechanisms and pathways.Journal of translational medicine · 2022Review
- Smoking-induced microbial dysbiosis in health and disease.Clinical science (London, England : 1979) · 2022Review
- Microbiota in health and diseases.Signal transduction and targeted therapy · 2022Review
- The Oral-Microbiome-Brain Axis and Neuropsychiatric Disorders: An Anthropological Perspective.Frontiers in psychiatry · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Recent studies have shown a critical role of the gastrointestinal microbiome in brain and behavior via the complex gut-microbiome-brain axis. However, the influence of the oral microbiome in neurological processes is much less studied, especially in response to the stimuli, such as smoking, within the oral microenvironment. Additionally, given the complex structural and functional networks in brain, our knowledge about the relationship between microbiome and brain function through specific brain circuits is still very limited. In this pilot study, we leveraged next generation sequencing for microbiome and functional neuroimaging technique to enable the delineation of microbiome-brain network links as well as their relationship to cigarette smoking. Thirty smokers and 30 age- and sex-matched nonsmokers were recruited for 16S sequencing of their oral microbial community. Among them, 56 subjects were scanned by resting-state functional magnetic resonance imaging to derive brain functional networks. Statistical analyses were performed to demonstrate the influence of smoking on the oral microbial composition, functional network connectivity, and the associations between microbial shifts and functional network connectivity alternations. Compared to nonsmokers, we found a significant decrease of beta diversity (P = 6 × 10
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.