Evidence map›Paper›PMID 31201891›Full record

Observational studyThe Journal of allergy and clinical immunology2019

Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort.

Anna Pomés, Jill Glesner, Agustin Calatroni, Cindy M Visness, Robert A Wood, George T O'Connor, Meyer Kattan, Leonard B Bacharier, Lisa M Wheatley, James E Gern and 2 more

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Indoor Allergen Interventions in Homes and Schools for Managing Asthma.The journal of allergy and clinical immunology. In practice · 2025
    Review
  4. Article
  5. Effective delivery of miR-511-3p with mannose-decorated exosomes with RNA nanoparticles confers protection against asthma.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Article
  6. Indoor Environmental Exposures and Their Relationship to Allergic Diseases.The journal of allergy and clinical immunology. In practice · 2023
    Article
  7. Article
  8. Allergic rhinitis co-morbidity on asthma outcomes in city school children.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023
    Article
  9. Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Development of nasal allergen challenge with cockroach in children with asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021
    Article
  15. Review
  16. Review
  17. Asthma epidemiology and risk factors.Seminars in immunopathology · 2020
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Anna PomésIndoor Biotechnologies, Inc, Basic Research, Charlottesville, Va. Electronic address: apomes@inbio.com.
Jill GlesnerIndoor Biotechnologies, Inc, Basic Research, Charlottesville, Va.
Agustin CalatroniRho Federal Systems Division, Chapel Hill, NC.
Cindy M VisnessRho Federal Systems Division, Chapel Hill, NC.
Robert A WoodDepartments of Pediatrics and Allergy and Immunology, Johns Hopkins University, Baltimore, Md.
George T O'ConnorDepartment of Medicne, Boston University School of Medicine, Boston, Mass.
Meyer KattanDepartment of Pediatrics, Columbia University, New York, NY.
Leonard B BacharierDepartment of Pediatrics, Washington University School of Medicine, St Louis, Mo.
Lisa M WheatleyDivision of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Bethesda, Md.
James E GernDepartments of Pediatrics and Medicine, University of Wisconsin-Madison, Madison, Wis.
William W BusseDepartments of Pediatrics and Medicine, University of Wisconsin-Madison, Madison, Wis.
National Institute of Allergy and Infectious Diseases–funded Inner-City Asthma Consortium
Columbia University · USIndoor Biotechnologies (United States) · USNational Institute of Allergy and Infectious Diseases · USRho (United States) · USUniversity of Wisconsin–Madison · USBoston University · USJohns Hopkins University · USWashington University in St. Louis · US

Funding

Transplantation GroupUM2AI117870 · NIAID · RHO FEDERAL SYSTEMS DIVISION, INC. · PI DAVID, GLORIA · 2015 to 2023
$208.1M
Inner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
ZIPRASIDONE (GEODON) AUGMENTATION IN SEROTONIN REUPTAKE INHIBITOR-RESISTANT OBM01RR000071 · NCRR · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI NEWCORN, JEFFREY H · 1985 to 2009
$41.5M
ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BELCHER, HAROLYN MILLICENT EDITH · 1985 to 2007
$37.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
YOGA INDUCED CHANGES IN BRAIN GABA LEVELSM01RR000533 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HOLICK, MICHAEL F. · 1985 to 2008
$19.4M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025771 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CENTER, DAVID M. · 2008 to 2011
$17.6M
Antigenic determinants of asthma-associated allergens for design of immunotherapy.R01AI077653 · NIAID · INDOOR BIOTECHNOLOGIES · PI MARTIN D. CHAPMAN, Maksymilian Chruszcz · 2009 to 2026
$9.5M
Inner-City Asthma Consortium-266025496-266025496N01AI025496 · NIAID · UNIVERSITY OF WISCONSIN · PI BUSSE, WILLIAM · 2002 to 2006
–
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCRR NIH HHS M01 RR000052NCRR NIH HHS M01 RR000071NCRR NIH HHS M01 RR000533NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR024992NCRR NIH HHS UL1 RR025771NIAID NIH HHS HHSN272200900052CNIAID NIH HHS HHSN272201000052INIAID NIH HHS N01 AI025482NIAID NIH HHS N01 AI025496NIAID NIH HHS R01 AI077653NIAID NIH HHS UM1 AI114271NIAID NIH HHS UM2 AI117870
6 · The paper itself

Abstract

backgroundCockroach is one of the most important sources of indoor allergens and can lead to IgE sensitization and development of rhinitis and asthma.

objectiveWe sought to perform a cockroach allergen component analysis to determine the allergens and antibody levels and patterns of sensitization associated with asthma and rhinitis.

methodsAntibody (IgE, IgG, and IgG

resultsIgE antibody levels to cockroach allergens and extract, but not IgG or IgG

conclusionsComponent analysis of 8 cockroach allergens revealed significant differences in IgE reactivity associated with the presence of asthma and rhinitis. Allergen-specific IgE titers and sensitization profiles were associated with asthma and rhinitis.

Indexed as

AllergensAnimalsAsthmaChildCockroachesCohort StudiesEnvironmental ExposureFemaleHumansImmunoglobulin EMaleRhinitisUrban PopulationAllergensImmunoglobulin Easthmacockroach allergen componentsCockroach allergydiagnosisimmunotherapyrhinitis

Identifiers

PMID31201891
PMCPMC7307589
OpenAlexW2950643796

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.