Evidence map›Paper›PMID 31201437›Full record

SynthesisDiabetologia2019

Effects of dietary and physical activity interventions on the risk of type 2 diabetes in South Asians: meta-analysis of individual participant data from randomised controlled trials.

Anne Karen Jenum, Idunn Brekke, Ibrahimu Mdala, Mirthe Muilwijk, Ambady Ramachandran, Marte Kjøllesdal, Eivind Andersen, Kåre R Richardsen, Anne Douglas, Genevieve Cezard and 9 more

Open access · bronzeAbstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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  11. Perspectives and Beliefs Surrounding Postpartum Care and Physical Activity of South Asian Immigrant Women in Canada.The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 4 countries.

Anne Karen JenumGeneral Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, Faculty of Medicine, University of Oslo, Post Box 1130 Blindern, 0318, Oslo, Norway. a.k.jenum@medisin.uio.no.
Idunn BrekkeCentre for Welfare and Labour Research, Norwegian Social Research, OsloMet - Oslo Metropolitan University, Oslo, Norway.
Ibrahimu MdalaGeneral Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, Faculty of Medicine, University of Oslo, Post Box 1130 Blindern, 0318, Oslo, Norway.
Mirthe MuilwijkDepartment of Public Health, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam, the Netherlands.
Ambady RamachandranIndia Diabetes Research Foundation, Chennai, India.
Marte KjøllesdalDepartment of Community Medicine and Global Health, Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
Eivind AndersenFaculty of Humanities, Sports and Educational Science, University of South-Eastern Norway, Borre, Norway.
Kåre R RichardsenDepartment of Physiotherapy, Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, Oslo, Norway.
Anne DouglasUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Genevieve CezardUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Aziz SheikhUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Carlos A Celis-MoralesInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Jason M R GillInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Naveed SattarInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Raj S BhopalUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Erik BeuneDepartment of Public Health, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam, the Netherlands.
Karien StronksDepartment of Public Health, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam, the Netherlands.
Per Olav VandvikDepartment of Medicine, Innlandet Hospital Trust, Gjøvik, Norway.
Irene G M van ValkengoedDepartment of Public Health, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam, the Netherlands.
University of Edinburgh · GBGGD Amsterdam · NLUniversity of Glasgow · GBUniversity of Oslo · NOOsloMet – Oslo Metropolitan University · NOIndia Diabetes Research Foundation · INInnlandet Hospital Trust · NOUniversity of Amsterdam · NLUniversity of South-Eastern Norway · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisIndividuals of South Asian origin have a high risk of type 2 diabetes and of dying from a diabetes-attributable cause. Lifestyle modification intervention trials to prevent type 2 diabetes in high-risk South Asian adults have suggested more modest effects than in European-origin populations. The strength of the evidence of individual studies is limited, however. We performed an individual participant data meta-analysis of available RCTs to assess the effectiveness of lifestyle modification in South Asian populations worldwide.

methodsWe searched PubMed, EMBASE, Cochrane Library and Web of Science (to 24 September 2018) for RCTs on lifestyle modification interventions incorporating diet and/or physical activity in South Asian adults. Reviewers identified eligible studies and assessed the quality of the evidence. We obtained individual participant data on 1816 participants from all six eligible trials (four from Europe and two from India). We generated HR estimates for incident diabetes (primary outcome) and mean differences for fasting glucose, 2 h glucose, weight and waist circumference (secondary outcomes) using mixed-effect meta-analysis overall and by pre-specified subgroups. We used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system to rate the quality of evidence of the estimates. The study is registered with the International Prospective Register of Systematic Reviews ([PROSPERO] CRD42017078003).

resultsIncident diabetes was observed in 12.6% of participants in the intervention groups and in 20.0% of participants in the control groups. The pooled HR for diabetes incidence was 0.65 (95% CI 0.51, 0.81; I CONCLUSIONS/

interpretationDespite modest changes for adiposity, lifestyle modification interventions in high-risk South Asian populations resulted in a clinically important 35% relative reduction in diabetes incidence, consistent across subgroups. If implemented on a large scale, lifestyle modification interventions in high-risk South Asian populations in Europe would reduce the incidence of diabetes in these populations.

Indexed as

Asian PeopleDietExerciseAdiposityAdultAgedAged, 80 and overBlood GlucoseBody Mass IndexBody WeightDiabetes Mellitus, Type 2EuropeFemaleHumansIncidenceIndiaBlood GlucoseDietIndividual participant data meta-analysisLifestyle interventionPhysical activityPreventionRCTSouth AsiansType 2 diabetes

Identifiers

PMID31201437
OpenAlexW2949287532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.