ReviewNature reviews. Rheumatology2019
Establishing outcome measures in early knee osteoarthritis.
Review in Nature reviews. Rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transcranial direct current stimulation for pain threshold in knee osteoarthritis: a mechanism-oriented systematic review and meta-analysis of randomized controlled trials.Frontiers in physiology · 2026Pooled it
- Decreased Synovial Fluid Biomarkers Levels Are Associated with Rehabilitation of Function and Pain in Rotator Cuff Tear Patients Following Electroacupuncture Therapy.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- A novel integrative multi-scale framework of inflammation and mechanical loading in knee osteoarthritis.Biomechanics and modeling in mechanobiology · 2026Article
- Baseline 3D joint space width on weight-bearing CT in comparison with 2D JSWOsteoarthritis imaging · 2026Article
- Knee Joint Motion Detection Based on Demodulation of Overlapping Spectrum Using Fiber Bragg Grating Sensor.Sensors (Basel, Switzerland) · 2026Article
- Serum levels of MMP3 could be used as a potential biomarker for sports-induced knee osteoarthritis.Journal of medical biochemistry · 2026Article
- Multimodal magnetic resonance imaging of the vastus medialis for quantitative diagnosis and grading in early-stage knee osteoarthritis and its correlation with severity.Scientific reports · 2026Article
- Article
- Diffusion model-empowered patella shape analysis predicts knee osteoarthritis outcomes.Osteoarthritis and cartilage open · 2025Article
- Adaptation of the knee quality of life 26-item questionnaire to turkish: cultural adaptation, reliability, and validity.Clinical rheumatology · 2025Article
- Article
- Functional data analysis of ground reaction forces combined with clinical measures for early knee osteoarthritis detection.Scientific reports · 2025Article
- CRTAC1 derived from senescent FLSs induces chondrocyte mitochondrial dysfunctionActa pharmaceutica Sinica. B · 2025Article
- MRI-based patient-specific nomogram for diagnostic risk stratification of patients with early knee OA.Rheumatology (Oxford, England) · 2025Article
- Article
- Quantitative Ultrashort Echo Time Magnetization Transfer Imaging of the Osteochondral Junction: An In Vivo Knee Osteoarthritis Study.Journal of imaging · 2025Article
- Associations between knee pain and knee-loading physical activities at work and leisure - a cross-sectional study based on accelerometer measurements.BMC musculoskeletal disorders · 2025Observational
- Evaluating Criteria for Symptoms Suggestive of Early Osteoarthritis Over Two Years Post-Anterior Cruciate Ligament Reconstruction: Data From the New Zealand Anterior Cruciate Ligament Registry.Arthritis care & research · 2025Article
- Integration of longitudinal load-bearing tissue MRI radiomics and neural network to predict knee osteoarthritis incidence.Journal of orthopaedic translation · 2025Article
- [Biomarkers and Their Role in Understanding Osteoarthritis].Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca · 2025Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Funding
Abstract
The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.
Indexed as
Identifiers
31201386What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.