ArticleNature communications2019
Orchestrated ensemble activities constitute a hippocampal memory engram.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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91citing papers in PubMed
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Who cites it
91 citing papers in PubMed.
- Miniscope Zero: a fully wireless, single-cell-resolution miniature microscope for imaging neural dynamics in freely behaving animals.bioRxiv : the preprint server for biology · 2026Article
- Biophysical mechanisms underlying the generation and maintenance of rule-learning engram.Communications biology · 2026Article
- CA1 Engram Cell Dynamics Before and After Learning.bioRxiv : the preprint server for biology · 2026Article
- Contamination of Engram Coactivity Networks During Forgetting.bioRxiv : the preprint server for biology · 2026Article
- Activation of Kv7.3 channels in mPFC engram neurons suppresses methamphetamine memory retrieval by reducing excitability and glutamate release in the mPFC-NAc circuit.Cellular and molecular life sciences : CMLS · 2026Article
- Timing and Convergence of Ensemble Activity Govern Auditory Thalamocortical Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Local Neuronal Ensembles That Coreactivate across Regions during Sleep Are Preferentially Stabilized.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neural substrate of conditioned stimulus for associative learning in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons.Frontiers in aging neuroscience · 2026Review
- Ethical imperatives in the commercialization of brain-computer interfaces.IBRO neuroscience reports · 2025Article
- Polarized ATP synthase in synaptic mitochondria induced by learning and plasticity signals.Communications biology · 2025Article
- Unpredictable stress boosts perceptual learning and alters glucocorticoid and norepinephrine receptors in rats' dorsal hippocampus.Translational psychiatry · 2025Article
- Immediate-early genes Arc and c-Fos show divergent brain-wide expression following contextual fear conditioning.Communications biology · 2025Article
- Long-Term Memory Engrams From Development to Adulthood.Hippocampus · 2025Review
- A Positive Allosteric Modulator of the SERCA Pump Rescues Hippocampal Neuronal Circuits Dysfunction and Cognitive Defects in a Mouse Model of Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The medial prefrontal cortex encodes procedural rules as sequential neuronal activity dynamics.Molecular brain · 2025Article
- Predictive learning rules generate a cortical-like replay of probabilistic sensory experiences.eLife · 2025Article
- Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep.Nature communications · 2025Article
- A comprehensive suite for extracting neuron signals across multiple sessions in one-photon calcium imaging.Nature communications · 2025Article
- Brain-wide immunolabeling and tissue clearing applications for engram research.Neurobiology of learning and memory · 2025Review
31 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors.
Khaled GhandourDepartment of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.ORCID http://orcid.org/0000-0002-7354-7918
Noriaki OhkawaDepartment of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. nohkawa@med.u-toyama.ac.jp.
Chi Chung Alan FungCREST, Japan Science and Technology Agency (JST), Toyama, 930-0194, Japan.ORCID http://orcid.org/0000-0002-7780-8230
Hirotaka AsaiDepartment of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Yoshito SaitohDepartment of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Takashi TakekawaCREST, Japan Science and Technology Agency (JST), Toyama, 930-0194, Japan.ORCID http://orcid.org/0000-0002-0821-9109
Reiko Okubo-SuzukiDepartment of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Shingo SoyaWPI-IIIS, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Hirofumi NishizonoCREST, Japan Science and Technology Agency (JST), Toyama, 930-0194, Japan.
Mina MatsuoLife Sciences Research Center, University of Toyama, Toyama, 930-0194, Japan.
Makoto OsanaiTohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.ORCID http://orcid.org/0000-0002-3572-8195
Masaaki SatoRIKEN Center for Brain Science, Hirosawa 2-1, Wako, Saitama, 351-0198, Japan.
Masamichi OhkuraGraduate School of Sciences and Engineering, Saitama University, 255 Shimo-Okubo, Sakura-ku, Saitama, 338-8570, Japan.
Junichi NakaiGraduate School of Sciences and Engineering, Saitama University, 255 Shimo-Okubo, Sakura-ku, Saitama, 338-8570, Japan.
Yasunori HayashiRIKEN Center for Brain Science, Hirosawa 2-1, Wako, Saitama, 351-0198, Japan.ORCID http://orcid.org/0000-0002-7560-3004
Takeshi SakuraiWPI-IIIS, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Takashi KitamuraDepartment of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-9070, USA.ORCID http://orcid.org/0000-0001-5597-859X
Tomoki FukaiCREST, Japan Science and Technology Agency (JST), Toyama, 930-0194, Japan.ORCID http://orcid.org/0000-0001-6977-5638
Kaoru InokuchiDepartment of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. inokuchi@med.u-toyama.ac.jp.ORCID http://orcid.org/0000-0002-5393-3133
Funding
MEXT | Japan Society for the Promotion of Science (JSPS) JP15H05723MEXT | Japan Society for the Promotion of Science (JSPS) JP16H04653MEXT | Japan Society for the Promotion of Science (JSPS) JP16H06276MEXT | Japan Society for the Promotion of Science (JSPS) JP18H02595MEXT | Japan Society for the Promotion of Science (JSPS) JP18H05213MEXT | Japan Society for the Promotion of Science (JSPS) JP23220009MEXT | Japan Society for the Promotion of Science (JSPS) JP26640008MEXT | JST | Core Research for Evolutional Science and Technology (CREST) JPMJCR13W1MEXT | JST | Precursory Research for Embryonic Science and Technology (PRESTO) JPMJPR1684
Abstract
The brain stores and recalls memories through a set of neurons, termed engram cells. However, it is unclear how these cells are organized to constitute a corresponding memory trace. We established a unique imaging system that combines Ca
Indexed as
AnimalsBrain MappingFemaleHippocampusIntravital MicroscopyLuminescent ProteinsMaleMemoryMice, Inbred C57BLMice, Inbred ICRMice, TransgenicMicroscopy, FluorescenceModels, AnimalNeuronsOptical ImagingOptogeneticsLuminescent Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.