ArticleNature communications2019
Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Motor neurons organize Drosophila feeding sequences via a disinhibitory cascade.Nature neuroscience · 2026Article
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- Multiple Scales of Coordination along the Body Axis duringThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Segmentally repeated ventral nerve cord circuits drive different leg rubbing behaviors iniScience · 2026Article
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- Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion.Genes & development · 2026Article
- Tonically active interneurons gate motor output inbioRxiv : the preprint server for biology · 2026Article
- Neural substrates of cold nociception ineLife · 2025Article
- Behavioral resilience via dynamic circuit firing homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Inhibitory circuit motifs in Drosophila larvae generate motor program diversity and variability.PLoS biology · 2025Article
- Triggering and modulation of a complex behavior by a single peptidergic command neuron inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- CRASH2p: Closed-loop Two Photon Imaging in a Freely Moving Animal.bioRxiv : the preprint server for biology · 2024Article
- Activity of nested neural circuits drives different courtship songs in Drosophila.Nature neuroscience · 2024Article
- Neuromuscular basis ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Synchronous multi-segmental activity between metachronal waves controls locomotion speed ineLife · 2023Article
- Linking neural circuits to the mechanics of animal behavior inFrontiers in neural circuits · 2023Review
- A vacuum-actuated soft robot inspired by Drosophila larvae to study kinetics of crawling behaviour.PloS one · 2023Article
- A neuromechanical model for Drosophila larval crawling based on physical measurements.BMC biology · 2022Article
- Hunchback activates Bicoid in Pair1 neurons to regulate synapse number and locomotor circuit function.Current biology : CB · 2022Article
- The two-body problem: Proprioception and motor control across the metamorphic divide.Current opinion in neurobiology · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Animal locomotion requires spatiotemporally coordinated contraction of muscles throughout the body. Here, we investigate how contractions of antagonistic groups of muscles are intersegmentally coordinated during bidirectional crawling of Drosophila larvae. We identify two pairs of higher-order premotor excitatory interneurons present in each abdominal neuromere that intersegmentally provide feedback to the adjacent neuromere during motor propagation. The two feedback neuron pairs are differentially active during either forward or backward locomotion but commonly target a group of premotor interneurons that together provide excitatory inputs to transverse muscles and inhibitory inputs to the antagonistic longitudinal muscles. Inhibition of either feedback neuron pair compromises contraction of transverse muscles in a direction-specific manner. Our results suggest that the intersegmental feedback neurons coordinate contraction of synergistic muscles by acting as delay circuits representing the phase lag between segments. The identified circuit architecture also shows how bidirectional motor networks could be economically embedded in the nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.