Evidence map›Paper›PMID 31201268›Full record

ArticleThe Journal of biological chemistry2019

A polymorphism in intron I of the human angiotensinogen gene (

Brahmaraju Mopidevi, Meenakshi K Kaw, Indu Sivankutty, Sudhir Jain, Sravan Kumar Perla, Ashok Kumar

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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  5. No Association BetweenDiabetes, metabolic syndrome and obesity : targets and therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Brahmaraju MopideviDepartment of Pathology, New York Medical College, Valhalla, New York 10595.
Meenakshi K KawDepartment of Physiology and Pharmacology, University of Toledo, Toledo, Ohio 43614.
Indu SivankuttyDepartment of Pathology, New York Medical College, Valhalla, New York 10595.
Sudhir JainDepartment of Pathology, New York Medical College, Valhalla, New York 10595.
Sravan Kumar PerlaDepartment of Pathology, New York Medical College, Valhalla, New York 10595.
Ashok KumarDepartment of Pathology, New York Medical College, Valhalla, New York 10595 akumar5@nymc.edu.
New York Medical College · USUniversity of Toledo · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Aldosterone Synthase & HypertensionR01HL122742 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI KUMAR, ASHOK · 2014 to 2017
$2.5M
Non-Coding Variants of Angiotensinogen Gene and HypertensionR01HL130344 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI KUMAR, ASHOK · 2016 to 2019
$2.4M
NovaSeq Shared Instrumentation Grant for Wayne State UniversityS10OD025170 · OD · WAYNE STATE UNIVERSITY · PI RUDEN, DOUGLAS M · 2018 to 2018
$600k
NCI NIH HHS P30 CA023108NHLBI NIH HHS R01 HL122742NHLBI NIH HHS R01 HL130344NIH HHS S10 OD025170
6 · The paper itself

Abstract

Angiotensinogen (AGT) is the precursor of one of the most potent vasoconstrictors, peptide angiotensin II. Genome-wide association studies have shown that two A/G polymorphisms (rs2493134 and rs2004776), located at +507 and +1164 in intron I of the human

Indexed as

Blood PressureAngiotensinogenAnimalsBinding SitesCCAAT-Enhancer-Binding Protein-betaChromatinHepatocyte Nuclear Factor 3-betaHep G2 CellsHumansIntronsLinkage DisequilibriumLiverMiceMice, Inbred C57BLMice, TransgenicPolymorphism, Single NucleotideAGT protein, humanAngiotensinogenCCAAT-Enhancer-Binding Protein-betaChromatinHepatocyte Nuclear Factor 3-betaReceptors, GlucocorticoidReninRNA, Messengerangiotensincardiovascular diseasegene expressiongeneticshypertensionrenin angiotensin systemsingle-nucleotide polymorphism (SNP)transgenic micevasopressor agent

Identifiers

PMID31201268
PMCPMC6682742
OpenAlexW2952392529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.