Evidence map›Paper›PMID 31201251›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

PARaDIM: A PHITS-Based Monte Carlo Tool for Internal Dosimetry with Tetrahedral Mesh Computational Phantoms.

Lukas M Carter, Troy M Crawford, Tatsuhiko Sato, Takuya Furuta, Chansoo Choi, Chan Hyeong Kim, Justin L Brown, Wesley E Bolch, Pat B Zanzonico, Jason S Lewis

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. IL13Rα2-Targeting Antibodies for Immuno-PET in Solid Malignancies.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  7. Article
  8. Article
  9. Interrogating the Theranostic Capacity of a MUC16-Targeted Antibody for Ovarian Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  10. MIB Guides: Preclinical Radiopharmaceutical Dosimetry.Molecular imaging and biology · 2024
    Article
  11. Research square · 2023
    Article
  12. Article
  13. Dosimetric variability across a library of computational tumor phantoms.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  14. Statins enhance the efficacy of HER2-targeting radioligand therapy in drug-resistant gastric cancers.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Review
  16. MIRD Pamphlet No. 27: MIRDcell V3, a Revised Software Tool for Multicellular Dosimetry and Bioeffect Modeling.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  17. Delta-like ligand 3-targeted radioimmunotherapy for neuroendocrine prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Article
  19. Review
  20. Personalized dosimetry ofBiomedical physics & engineering express · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lukas M CarterProgram in Pharmacology, the Radiochemistry and Molecular Imaging Probes Core, and the Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Troy M CrawfordDepartment of Physics, University of Rhode Island, Kingston, Rhode Island.
Tatsuhiko SatoJapan Atomic Energy Agency, Ibaraki, Japan.
Takuya FurutaJapan Atomic Energy Agency, Ibaraki, Japan.
Chansoo ChoiDepartment of Nuclear Engineering, Hanyang University, Seoul, Korea.
Chan Hyeong KimDepartment of Nuclear Engineering, Hanyang University, Seoul, Korea.
Justin L BrownJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida.
Wesley E BolchJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida.
Pat B ZanzonicoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York; and.
Jason S LewisProgram in Pharmacology, the Radiochemistry and Molecular Imaging Probes Core, and the Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York lewisj2@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Development of a Novel Peptide Platform for Targeted PET Imaging and Radiotherapy of Breast CancerF32EB025050 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI CARTER, LUKAS MICHAEL · 2017 to 2019
$179k
NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA232130NIBIB NIH HHS F32 EB025050
6 · The paper itself

Abstract

Mesh-type and voxel-based computational phantoms comprise the current state of the art for internal dose assessment via Monte Carlo simulations but excel in different aspects, with mesh-type phantoms offering advantages over their voxel counterparts in terms of their flexibility and realistic representation of detailed patient- or subject-specific anatomy. We have developed PARaDIM (pronounced "paradigm": Particle and Heavy Ion Transport Code System-Based Application for Radionuclide Dosimetry in Meshes), a freeware application for implementing tetrahedral mesh-type phantoms in absorbed dose calculations. It considers all medically relevant radionuclides, including α, β, γ, positron, and Auger/conversion electron emitters, and handles calculation of mean dose to individual regions, as well as 3-dimensional dose distributions for visualization and analysis in a variety of medical imaging software. This work describes the development of PARaDIM, documents the measures taken to test and validate its performance, and presents examples of its uses.

Indexed as

Monte Carlo MethodPhantoms, ImagingAnimalsMiceRadiometrydosimetryPARaDIMphantomPHITStetrahedral mesh

Identifiers

PMID31201251
PMCPMC6894378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.