Evidence map›Paper›PMID 31201250›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2020

Benjamin P Burke, Cecilia S Miranda, Rhiannon E Lee, Isaline Renard, Shubhanchi Nigam, Gonçalo S Clemente, Thomas D'Huys, Torsten Ruest, Juozas Domarkas, James A Thompson and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Synthesis andChemMedChem · 2025
    Article
  3. Review
  4. Selective PET imaging of CXCR4 using the AlEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Dalton transactions (Cambridge, England : 2003) · 2024
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Benjamin P BurkeDepartment of Chemistry, University of Hull, Hull, United Kingdom.
Cecilia S MirandaPositron Emission Tomography Research Centre, University of Hull, Hull, United Kingdom.
Rhiannon E LeeDepartment of Chemistry, University of Hull, Hull, United Kingdom.
Isaline RenardDepartment of Chemistry, University of Hull, Hull, United Kingdom.
Shubhanchi NigamPositron Emission Tomography Research Centre, University of Hull, Hull, United Kingdom.
Gonçalo S ClementePositron Emission Tomography Research Centre, University of Hull, Hull, United Kingdom.
Thomas D'HuysRega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Torsten RuestDepartment of Biomedical Sciences, University of Hull, Hull, United Kingdom.
Juozas DomarkasDepartment of Chemistry, University of Hull, Hull, United Kingdom.
James A ThompsonPositron Emission Tomography Research Centre, University of Hull, Hull, United Kingdom.
Timothy J HubinDepartment of Chemistry and Physics, Southwestern Oklahoma State University, Weatherford, Oklahoma.
Dominique ScholsRega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Christopher J CawthornePositron Emission Tomography Research Centre, University of Hull, Hull, United Kingdom.
Stephen J ArchibaldDepartment of Chemistry, University of Hull, Hull, United Kingdom s.j.archibald@hull.ac.uk.
University of Hull · GBRega Institute for Medical Research · BESouthwestern Oklahoma State University · US

Funding

Proteomics CoreP20GM103447 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Mark L Lang · 2012 to 2026
$60.2M
NIGMS NIH HHS P20 GM103447
6 · The paper itself

Abstract

Expression of the chemokine receptor chemokine C-X-C motif receptor 4 (CXCR4) plays an important role in cancer metastasis, in autoimmune diseases, and during stem cell-based repair processes after stroke and myocardial infarction. Previously reported PET imaging agents targeting CXCR4 suffer from either high nonspecific uptake or bind only to the human form of the receptor. The objective of this study was to develop a high-stability

Indexed as

AnimalsBenzylaminesCell Line, TumorChelating AgentsCopper RadioisotopesCyclamsFemaleHeterocyclic CompoundsHumansImage Processing, Computer-AssistedLiverMiceMice, NudeNeoplasm TransplantationPositron-Emission TomographyProtein BindingBenzylaminesChelating AgentsCopper RadioisotopesCXCR4 protein, humanCyclamsHeterocyclic CompoundsN-(1,4,8,11- tetraazacyclotetradecanyl-1,4-phenylenebis(methylene))-2-(aminomethyl)- pyridineplerixaforPyridinesRadiopharmaceuticalsReceptors, CXCR464CuAMD3100azamacrocycleCXCR4cyclam

Identifiers

PMID31201250
PMCPMC9374041
OpenAlexW2952457511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.