Evidence map›Paper›PMID 31201232›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments.

Nobutake Hosoi, Koji Shibasaki, Mayu Hosono, Ayumu Konno, Yo Shinoda, Hiroshi Kiyonari, Kenichi Inoue, Shin-Ichi Muramatsu, Yasuki Ishizaki, Hirokazu Hirai and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. A compact GAD67 promoter enables inhibitory neuron-targeted AAV gene therapy for seizure suppression.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  2. Article
  3. Article
  4. Genomic Markers for Essential Tremor.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  5. Article
  6. ARF family GTPases with links to cilia.American journal of physiology. Cell physiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Nobutake HosoiDepartments of Neurophysiology and Neural Repair, sadakata-1024@umin.ac.jp nhosoi@gunma-u.ac.jp.ORCID 0000-0002-7889-2542
Koji ShibasakiMolecular and Cellular Neurobiology.ORCID 0000-0003-2330-1749
Mayu HosonoEducation and Research Support Center, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
Ayumu KonnoDepartments of Neurophysiology and Neural Repair.ORCID 0000-0001-9382-396X
Yo ShinodaDepartment of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.ORCID 0000-0003-3253-2194
Hiroshi KiyonariGenetic Engineering Team.ORCID 0000-0002-1509-8747
Kenichi InoueLaboratory for Animal Resources, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan.
Shin-Ichi MuramatsuDepartment of Neurology, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan, and.ORCID 0000-0002-3185-7790
Yasuki IshizakiMolecular and Cellular Neurobiology.ORCID 0000-0002-1306-1123
Hirokazu HiraiDepartments of Neurophysiology and Neural Repair.ORCID 0000-0002-0721-4293
Teiichi FuruichiDepartment of Applied Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan.ORCID 0000-0002-9676-1888
Tetsushi SadakataEducation and Research Support Center, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan, sadakata-1024@umin.ac.jp nhosoi@gunma-u.ac.jp.ORCID 0000-0003-0276-4162
Gunma University · JPNeural Repair Institute · USRIKEN Center for Biosystems Dynamics Research · JPJichi Medical University · JPNeurological Surgery · USTokyo University of Pharmacy and Life Sciences · JPTokyo University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ADP-ribosylation factors (ARFs) are a family of small monomeric GTPases comprising six members categorized into three classes: class I (ARF1, 2, and 3), class II (ARF4 and 5), and class III (ARF6). In contrast to class I and III ARFs, which are the key regulators in vesicular membrane trafficking, the cellular function of class II ARFs remains unclear. In the present study, we generated class II ARF-deficient mice and found that ARF4

Indexed as

Action PotentialsADP-Ribosylation FactorsAnimalsAxonsDependovirusElectroencephalographyElectromyographyGenetic VectorsGenotypeHead MovementsMiceMice, Inbred C57BLMice, KnockoutMovement DisordersNAV1.6 Voltage-Gated Sodium ChannelPatch-Clamp TechniquesADP-Ribosylation FactorsARF4 protein, mouseArf5 protein, mouseNAV1.6 Voltage-Gated Sodium ChannelScn8a protein, mouseARFaxon initial segmentessential tremorsodium channel

Identifiers

PMID31201232
PMCPMC6687904
OpenAlexW2949270669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.