Evidence map›Paper›PMID 31201163›Full record

ArticleBiology open2019

The Y227N mutation affects bestrophin-1 protein stability and impairs sperm function in a mouse model of Best vitelliform macular dystrophy.

Andrea Milenkovic, Denise Schmied, Naoyuki Tanimoto, Mathias W Seeliger, Janet R Sparrow, Bernhard H F Weber

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Glial Chloride Channels in the Function of the Nervous System Across Species.Advances in experimental medicine and biology · 2021
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Andrea MilenkovicInstitute of Human Genetics, University of Regensburg, 93053 Regensburg, Germany.
Denise SchmiedInstitute of Human Genetics, University of Regensburg, 93053 Regensburg, Germany.
Naoyuki TanimotoDivision of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, 72076 Tübingen, Germany.
Mathias W SeeligerDivision of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, 72076 Tübingen, Germany.
Janet R SparrowDepartment of Ophthalmology, Harkness Eye Institute, Columbia University Medical Center, 10032 New York, USA.
Bernhard H F WeberInstitute of Human Genetics, University of Regensburg, 93053 Regensburg, Germany bweb@klinik.uni-regensburg.de.ORCID http://orcid.org/0000-0002-8808-7723
University of Regensburg · DEChristian-Albrechts-Universität zu Kiel · DEColumbia University Irving Medical Center · USSTZ eyetrial · DE

Funding

Instrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9M
IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLSR01EY012951 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPARROW, JANET RUTHE · 2000 to 2024
$8.9M
NEI NIH HHS P30 EY019007NEI NIH HHS R01 EY012951
6 · The paper itself

Abstract

Human bestrophin-1 (BEST1) is an integral membrane protein known to function as a Ca

Indexed as

BEST1Best1Y227N knock-in mouseBestrophin-1Protein stabilitySperm motilityVitelliform macular dystrophy

Identifiers

PMID31201163
PMCPMC6679414
OpenAlexW2952137798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.