ArticleNeuron2019
Cerebellar Contribution to Preparatory Activity in Motor Neocortex.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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Who cites it
108 citing papers in PubMed.
- Investigating the feasibility of cerebellar transcranial direct current stimulation to facilitate post-stroke overground gait performance in chronic stroke: a partial least-squares regression approach.Journal of neuroengineering and rehabilitation · 2021Trial
- Purkinje Cells in Crus I and II Encode the Visual Stimulus and the Impending Choice as Monkeys Learn a Reinforcement-Based Visuomotor Association Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cerebellar neural populations orchestrate dopamine reward signaling with single-trial precision.Nature communications · 2026Article
- Cerebellar perturbation impairs human working memory and degrades spatial tuning throughout cortex.bioRxiv : the preprint server for biology · 2026Article
- Cerebellar acceleration of learning in an evidence-accumulation task.Cell reports · 2026Article
- Contribution of the anterior lateral motor cortex to predictive postural control in rats.Scientific reports · 2026Article
- Cerebellar Time and Relative Time: A Comparator-Based Dynamical Timing Model and its Relevance to Psychopathology and Therapies.Cerebellum (London, England) · 2026Review
- Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026Review
- Effects of Short-Term Synaptic Plasticity in Feedforward Inhibitory Circuits on Cerebellar Responses to Repetitive Sensory Input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- tACS of the Cerebellum and the Motor Cortex Entrains the Spiking Activity of the Cells in Motor Thalamus in a Frequency Dependent Manner.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Autism Spectrum Disorder: The Cerebellum, Genes, and Pathways.Neurology international · 2025Review
- Stage-dependent cerebrocerebellar communication during sensorimotor processing.Nature communications · 2025Article
- Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning.Current biology : CB · 2025Article
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- A cerebello-thalamo-cortical pathway transmits reward-based post-error signals for motor timing correction during learning in male mice.Nature communications · 2025Article
- Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning.bioRxiv : the preprint server for biology · 2025Article
- Synergistic Reinforcement Learning by Cooperation of the Cerebellum and Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Fast implicit and slow explicit learning of temporal context.Scientific reports · 2025Article
- Purkinje cells of the cerebellum control deceleration of tongue movements.PLoS biology · 2025Article
- Cerebellar output shapes cortical preparatory activity during motor adaptation.Nature communications · 2025Article
48 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
In motor neocortex, preparatory activity predictive of specific movements is maintained by a positive feedback loop with the thalamus. Motor thalamus receives excitatory input from the cerebellum, which learns to generate predictive signals for motor control. The contribution of this pathway to neocortical preparatory signals remains poorly understood. Here, we show that, in a virtual reality conditioning task, cerebellar output neurons in the dentate nucleus exhibit preparatory activity similar to that in anterolateral motor cortex prior to reward acquisition. Silencing activity in dentate nucleus by photoactivating inhibitory Purkinje cells in the cerebellar cortex caused robust, short-latency suppression of preparatory activity in anterolateral motor cortex. Our results suggest that preparatory activity is controlled by a learned decrease of Purkinje cell firing in advance of reward under supervision of climbing fiber inputs signaling reward delivery. Thus, cerebellar computations exert a powerful influence on preparatory activity in motor neocortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.