ArticlePediatric neurology2019
Early Detection of Cerebral Palsy Using Sensorimotor Tract Biomarkers in Very Preterm Infants.
Article in Pediatric neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Mapping white matter microstructure at term age to motor outcomes at 2 years in very preterm infants: a multicentre cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2026Article
- High-risk infant follow-up: current practice and factors determining eligibility.Pediatric research · 2026Article
- Methodological considerations on diffusion MRI tractography in infants aged 0-2 years: a scoping review.Pediatric research · 2025Article
- Review
- Strengthening Equitable Access to Care and Support for Children with Cerebral Palsy and Their Caregivers.Children (Basel, Switzerland) · 2023Article
- Identification of proprioceptive thalamocortical tracts in children: comparison of fMRI, MEG, and manual seeding of probabilistic tractography.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- White matter myelination during early infancy is linked to spatial gradients and myelin content at birth.Nature communications · 2022Article
- Artificial Intelligence-Based MRI in Diagnosis of Injury of Cranial Nerves of Premature Infant and Its Correlation with Inflammation of Placenta.Contrast media & molecular imaging · 2022Article
- A Review on Recent Advances of Cerebral Palsy.Oxidative medicine and cellular longevity · 2022Review
- Association between brain structural network efficiency at term-equivalent age and early development of cerebral palsy in very preterm infants.NeuroImage · 2021Article
- Early micro- and macrostructure of sensorimotor tracts and development of cerebral palsy in high risk infants.Human brain mapping · 2021Article
- Effects of intraventricular hemorrhage on white matter microstructural changes at term and early developmental outcomes in infants born very preterm.Neuroradiology · 2021Article
- Diffusion MRI Microstructural Abnormalities at Term-Equivalent Age Are Associated with Neurodevelopmental Outcomes at 3 Years of Age in Very Preterm Infants.AJNR. American journal of neuroradiology · 2021Article
- Early Diagnostics and Early Intervention in Neurodevelopmental Disorders-Age-Dependent Challenges and Opportunities.Journal of clinical medicine · 2021Review
- Novel diffuse white matter abnormality biomarker at term-equivalent age enhances prediction of long-term motor development in very preterm children.Scientific reports · 2020Article
- Ten-year trends in infant neuroimaging from US Neonatal Intensive Care Units.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Changes of Structural Brain Network Following Repetitive Transcranial Magnetic Stimulation in Children With Bilateral Spastic Cerebral Palsy: A Diffusion Tensor Imaging Study.Frontiers in pediatrics · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOur objectives were to evaluate the brain's sensorimotor network microstructure using diffusion magnetic resonance imaging (MRI) at term-corrected age and test the ability of sensorimotor microstructural parameters to accurately predict cerebral palsy in extremely-low-birth-weight infants.
methodsWe enrolled a prospective pilot cohort of extremely-low-birth-weight preterm infants (birth weight ≤ 1000 g) before neonatal intensive care unit discharge and studied them with structural and diffusion MRI at term-corrected age. Six sensorimotor tracts were segmented, and microstructural parameters from these tracts were evaluated for their ability to predict later development of cerebral palsy, diagnosed at 18 to 22 months corrected age.
resultsWe found significant differences in multiple diffusion MRI parameters from five of the six sensorimotor tracts in infants who developed cerebral palsy (n = 5) versus those who did not (n = 36). When compared with structural MRI or individual diffusion MRI biomarkers, the combination of two individual biomarkers-fractional anisotropy of superior thalamic radiations (sensory component) and radial diffusivity of the corticospinal tract-exhibited the highest sensitivity (80%), specificity (97%), and positive likelihood ratio (28.0) for prediction of cerebral palsy. This combination of diffusion MRI biomarkers accurately classified 95% of the study infants.
conclusionsDevelopment of cerebral palsy in very preterm infants is preceded by early brain injury or immaturity to one or more sensorimotor tracts. A larger study is warranted to evaluate if a combination of sensorimotor microstructural biomarkers could accurately facilitate early diagnosis of cerebral palsy.
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