Evidence map›Paper›PMID 31201062›Full record

ArticleBioorganic & medicinal chemistry letters2019

Exploring small molecules with pan-genotypic inhibitory activities against hepatitis C virus NS3/4A serine protease.

Jinhong Ren, Isabel Ojeda, Maulik Patel, Michael E Johnson, Hyun Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jinhong RenCenter for Biomolecular Sciences, University of Illinois at Chicago, 900 S. Ashland Ave, Chicago, IL 60607, USA.
Isabel OjedaCenter for Biomolecular Sciences, University of Illinois at Chicago, 900 S. Ashland Ave, Chicago, IL 60607, USA.
Maulik PatelCenter for Biomolecular Sciences, University of Illinois at Chicago, 900 S. Ashland Ave, Chicago, IL 60607, USA.
Michael E JohnsonCenter for Biomolecular Sciences, University of Illinois at Chicago, 900 S. Ashland Ave, Chicago, IL 60607, USA; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 S. Wood Street, IL 60612, USA. Electronic address: mjohnson@uic.edu.
Hyun LeeCenter for Biomolecular Sciences, University of Illinois at Chicago, 900 S. Ashland Ave, Chicago, IL 60607, USA; Biophysics Core at Research Resource Center, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 S. Wood Street, IL 60612, USA. Electronic address: danielhl@uic.edu.

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Center for Natural Product Technologies at UIC (CeNAPT)U41AT008706 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PAULI, GUIDO F · 2015 to 2019
$1.5M
Development of broad spectrum Hepatitis C Virus NS3/4A protease inhibitorsR41AI112114 · NIAID · NOVALEX THERAPEUTICS, INC. · PI JOHNSON, MICHAEL E., LEE, HYUN · 2014 to 2015
$600k
NCCIH NIH HHS U41 AT008706NIAID NIH HHS R41 AI112114NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Among the many Hepatitis C virus (HCV) genotypes and subtypes, genotypes 1b and 3a are most prevalent in United States and Asia, respectively. A total of 132 commercially available analogs of a previous lead compound were initially investigated against wild-type HCV genotype 1b NS3/4A protease. Ten compounds showed inhibitory activities (IC

Indexed as

Antiviral AgentsDEAD-box RNA HelicasesDose-Response Relationship, DrugGenotypeHepacivirusHumansMicrobial Sensitivity TestsMolecular StructureNucleoside-TriphosphataseProtease InhibitorsSerine EndopeptidasesSerine ProteasesSmall Molecule LibrariesStructure-Activity RelationshipViral Nonstructural ProteinsViral ProteasesAntiviral AgentsDEAD-box RNA HelicasesNS3-4A serine protease, Hepatitis C virusNS3 protein, hepatitis C virusNucleoside-TriphosphataseProtease InhibitorsSerine EndopeptidasesSerine ProteasesSmall Molecule LibrariesViral Nonstructural ProteinsViral ProteasesHepatitis C virusMolecular dockingMolecular dynamics simulationsNS3/4A proteasePan-genotypic inhibitors

Identifiers

PMID31201062
PMCPMC6690791

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.