Evidence map›Paper›PMID 31200941›Full record

ArticleKidney international2019

An international Delphi survey helped develop consensus-based core outcome domains for trials in peritoneal dialysis.

Karine E Manera, Allison Tong, Jonathan C Craig, Jenny Shen, Shilpa Jesudason, Yeoungjee Cho, Benedicte Sautenet, Armando Teixeira-Pinto, Martin Howell, Angela Yee-Moon Wang and 11 more

Open access · greenAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
31.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 102 citations in OpenAlex.

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  4. Patient-reported outcome measures for life participation in peritoneal dialysis: a systematic review.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 17 institutions in 9 countries.

Karine E ManeraSydney School of Public Health, The University of Sydney, Sydney, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Sydney, Australia. Electronic address: karine.manera@sydney.edu.au.
Allison TongSydney School of Public Health, The University of Sydney, Sydney, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Sydney, Australia.
Jonathan C CraigCollege of Medicine and Public Health, Flinders University, Adelaide, Australia.
Jenny ShenDivision of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, Torrance, California, USA.
Shilpa JesudasonCentral and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital and University of Adelaide, Adelaide, Australia.
Yeoungjee ChoDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, Australia; Australian Kidney Trials Network, University of Queensland, Brisbane, Australia.
Benedicte SautenetUniversity François Rabelais, Tours, France; Department of Nephrology-Hypertension, Dialysis, Kidney Transplantation, Tours Hospital, Tours, France; Methods in Patient-Centered Outcomes & Health Research, Institut National de la Santé et de la Recherche Médicale, U1246, Tours, France.
Armando Teixeira-PintoSydney School of Public Health, The University of Sydney, Sydney, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Sydney, Australia.
Martin HowellSydney School of Public Health, The University of Sydney, Sydney, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Sydney, Australia.
Angela Yee-Moon WangDepartment of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
Edwina A BrownImperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
Gillian BrunierSunnybrook Health Sciences Centre (retired), Toronto, Ontario, Canada.
Jeffrey PerlDivision of Nephrology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Jie DongRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Martin WilkieDepartment of Nephrology, Sheffield Teaching Hospitals National Health Service Foundation Trust, Sheffield, United Kingdom.
Rajnish MehrotraKidney Research Institute and Harborview Medical Center, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Roberto Pecoits-FilhoSchool of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil; Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
Saraladevi NaickerDepartment of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Tony DunningSouth Bank Technical and Further Education, Brisbane, Australia.
Nicole Scholes-RobertsonCentre for Kidney Research, The Children's Hospital at Westmead, Westmead, Sydney, Australia.
David W JohnsonDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, Australia; Australian Kidney Trials Network, University of Queensland, Brisbane, Australia; Translational Research Institute, Brisbane, Australia; Centre for Kidney Disease Research, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia.
The University of Sydney · AUChildren's Hospital at Westmead · AUFlinders University · AUHammersmith Hospital · GBNational Health Service · GBPeking University · CNPontifícia Universidade Católica do Paraná · BRQueen Mary Hospital · CNRoyal Adelaide Hospital · AUSt. Michael's Hospital · CASunnybrook Health Science Centre · CAThe University of Queensland · AUTranslational Research Institute · AUUniversité de Tours · FRUniversity of California, Los Angeles · USUniversity of the Witwatersrand · ZAUniversity of Washington · US

Funding

Trajectories of Adherence to Cardiovascular Medications in Patients on DialysisK23DK103972 · NIDDK · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI SHEN, JENNY I · 2015 to 2019
$934k
NIDDK NIH HHS K23 DK103972
6 · The paper itself

Abstract

Shared decision-making about clinical care options in end-stage kidney disease is limited by inconsistencies in the reporting of outcomes and the omission of patient-important outcomes in trials. Here we generated a consensus-based prioritized list of outcomes to be reported during trials in peritoneal dialysis (PD). In an international, online, three-round Delphi survey, patients/caregivers and health professionals rated the importance of outcomes using a 9-point Likert scale (with 7-9 indicating critical importance) and provided comments. Using a Best-Worst Scale (BWS), the relative importance of outcomes was estimated. Comments were analyzed thematically. In total, 873 participants (207 patients/caregivers and 666 health professionals) from 68 countries completed round one, 629 completed round two and 530 completed round three. The top outcomes were PD-related infection, membrane function, peritoneal dialysis failure, cardiovascular disease, death, catheter complications, and the ability to do usual activities. Compared with health professionals, patients/caregivers gave higher priority to six outcomes: blood pressure (mean difference, 0.4), fatigue (0.3), membrane function (0.3), impact on family/friends (0.1), peritoneal thickening (0.1) and usual activities (0.1). Four themes were identified that underpinned the reasons for ratings: contributing to treatment longevity, preserving quality of life, escalating morbidity, and irrelevant and futile information and treatment. Patients/caregivers and health professionals gave highest priority to clinical outcomes. In contrast to health professionals, patients/caregivers gave higher priority to lifestyle-related outcomes including the impact on family/friends and usual activities. Thus, prioritization will inform a core outcome set to improve the consistency and relevance of outcomes for trials in PD.

Indexed as

Kidney Failure, ChronicOutcome Assessment, Health CarePeritoneal DialysisPractice Guidelines as TopicRandomized Controlled Trials as TopicAdolescentAdultAgedDecision Making, SharedDelphi TechniqueFemaleHumansMaleMiddle AgedQuality of LifeSurveys and Questionnairescore outcome setskidney diseaseoutcomespatient-centered careperitoneal dialysistrials

Identifiers

PMID31200941
PMCPMC6961705
OpenAlexW2927981269

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.