ReviewCritical care (London, England)2019
Sepsis: personalization v protocolization?
Review in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Dynamic biomarker profiling and phenotyping in burn sepsis: a retrospective cohort study using growth mixture modeling.Frontiers in cellular and infection microbiology · 2026Article
- Parenclitic network mapping predicts survival in critically ill patients with sepsis.Physiological reports · 2025Article
- Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo.Life science alliance · 2023Article
- Precision Medicine in Pancreatitis: The Future of Acute Pancreatitis Care.Function (Oxford, England) · 2023Review
- Mitigation of Sepsis-Induced Acute Lung Injury by BMSC-Derived Exosomal miR-125b-5p Through STAT3-Mediated Suppression of Macrophage Pyroptosis.International journal of nanomedicine · 2023Article
- Pediatric sepsis phenotypes for enhanced therapeutics: An application of clustering to electronic health records.Journal of the American College of Emergency Physicians open · 2022Article
- A combined risk model for the multi-encompassing identification of heterogeneities of prognoses, biological pathway variations and immune states for sepsis patients.BMC anesthesiology · 2022Article
- The Necessity of Individualized Treatment for Sepsis-Associated Disseminated Intravascular Coagulation by Infected Organ.Open access emergency medicine : OAEM · 2022Article
- Making Waves: Will It Help Children with Traumatic Brain Injury?Neurocritical care · 2021Article
- Individualized Care Is Superior to Standardized Care for the Majority of Critically Ill Patients.Critical care medicine · 2020Article
- Clinical management of sepsis can be improved by artificial intelligence: no.Intensive care medicine · 2020Article
- The management of sepsis: science & fiction.Journal of thoracic disease · 2020Article
- Variation in the Outcome of Norepinephrine-Dependent Septic Patients After the Institution of aFrontiers in medicine · 2020Article
- Circulating Th1 and Th2 Subset Accumulation Kinetics in Septic Patients with Distinct Infection Sites: Pulmonary versus Nonpulmonary.Mediators of inflammation · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The founding tenet of evidence-based medicine is to combine best evidence with clinical expertise. As David Sackett opined 'Without clinical expertise, practice risks becoming tyrannised by evidence'. Rigid protocols and mandates, based on an inconclusive and low-level evidence base, cannot suit the physiological, biochemical and biological heterogeneity displayed by the individual septic patient. Indeed, clear proof of outcome benefit through adoption of an inflexible management approach is lacking and will certainly be detrimental to some. Therapy thus needs to be tailored to meet the individual patient's needs. The same principle should be applied to clinical trials; the continued disappointments of multiple investigational strategies trialled over three decades, despite (often) a sound biological rationale, suggest a repeated methodological failure that does not account for the marked heterogeneity within the septic patient's biological phenotype and thus marked variation in their host response. The increasing availability of rapid point-of-care diagnostics and theranostics should facilitate better patient selection and titrated optimization of the therapeutic intervention.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.