Evidence map›Paper›PMID 31200748›Full record

ArticleInfectious diseases of poverty2019

Surveillance of drug resistance tuberculosis based on reference laboratory data in Ethiopia.

Getu Diriba, Abebaw Kebede, Habteyes Hailu Tola, Ayinalem Alemu, Mengistu Tadesse, Epherem Tesfaye, Zemedu Mehamed, Abiyot Meaza, Bazezew Yenew, Hilina Molalign and 6 more

Open access · goldAbstract read
In one paragraph

Article in Infectious diseases of poverty, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Drug resistance pulmonary tuberculosis among prisoners in Ethiopia: A systematic review andJournal of clinical tuberculosis and other mycobacterial diseases · 2026
    Review
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  10. Tropical medicine and infectious disease · 2022
    Review
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  16. Drug Resistance Pattern ofInfection and drug resistance · 2021
    Article
  17. Observational
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Getu DiribaEthiopian Public Health Institute, Addis Ababa, Ethiopia. getud2020@gmail.com.
Abebaw KebedeEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Habteyes Hailu TolaEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Ayinalem AlemuEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Mengistu TadesseEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Epherem TesfayeEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Zemedu MehamedEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Abiyot MeazaEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Bazezew YenewEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Hilina MolalignEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Biniyam DagneEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Waganeh SinshawEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Misikir AmareEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Shewki MogaEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Yeshiwork AbebawEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Getachew SiedEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Ethiopian Public Health Institute · ET

Funding

Ethiopia-Emory TB Research Training ProgramD43TW009127 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Kidist Bobosha · 2013 to 2026
$3.4M
FIC NIH HHS D43 TW009127
6 · The paper itself

Abstract

backgroundBoth passive and active surveillance of drug resistance have an important role in tuberculosis (TB) control program. Surveillance data are important to estimate the magnitude of drug resistance TB, to know the trend of the disease, assess the performance of the program, and to forecast diagnosis and treatment supplies. Therefore, this study aimed to determine the prevalence and the proportion of drug resistant tuberculosis in Ethiopia based on passively collected data.

methodsA cross-sectional study was conducted at the National Tuberculosis Reference Laboratory and seven Regional TB laboratories in Ethiopia on a retrospective data collected from July 2017 to June, 2018. Data were collected by standardized checklist from TB culture laboratory registration book. Percentage of recovery rate, contamination rate, and prevalence of drug resistance TB were determined by Statistical Package for Social Science (SPSS) version 23.

resultOf 10 134 TB suspected individuals included into this analysis, 1183 (11.7%) were culture positive. The overall contamination proportion was 5.3% and nontuberculous mycobacteria proportion was 0.98%. First-line drug susceptibility test was performed for 329 Mycobacterium tuberculosis complex isolates, and the proportion of resistance was 5.7 and 6.3% for isoniazid and rifampicin respectively. The proportion of multidrug-resistant tuberculosis (MDR-TB) was 4.3% in new patients, while 6.7% in previously treated patients. However, there was no category for 0.6% patients, and the overall proportion of MDR-TB was 11.6%.

conclusionsThe result of this study indicated that MDR-TB is a serious public health problem in Ethiopia. Thus, strengthen prevention and control program is vital to halt the burden of drug resistant TB in the country.

Indexed as

Antitubercular AgentsCross-Sectional StudiesEthiopiaFemaleHumansIsoniazidMaleMycobacterium tuberculosisRetrospective StudiesRifampinTuberculosis, Multidrug-ResistantAntitubercular AgentsIsoniazidRifampinIsoniazid resistanceMultidrug-resistant tuberculosisRifampicin resistanceTuberculosis

Identifiers

PMID31200748
PMCPMC6567428
OpenAlexW2951334586

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.