ReviewCritical care (London, England)2019
Evolving concepts for safer ventilation.
Review in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04174014 (Estimation of Optimal PEEP by Transpulmonary Pressure Measurement Following Recruitment Manoeuvre Under Computer Tomography and Electric Impedance Tomography Control), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Estimation of Optimal PEEP by Transpulmonary Pressure Measurement Following Recruitment Manoeuvre Under Computer Tomography and Electric Impedance Tomography Control
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of driving pressure-limiting strategies on outcomes of patients with ARDS: a meta-analysis of randomized controlled trials.Critical care (London, England) · 2026Pooled it
- Mechanical power guided lung protective ventilation in acute respiratory failure using the VentCoach approach.Scientific reports · 2026Trial
- Determinants of Postoperative Pulmonary Complications and Optimization Strategies for Intraoperative Respiratory Management After Laparoscopic Gastrointestinal Cancer Surgery.Annals of surgical oncology · 2026Article
- Adjusting inspiratory rise time alters mechanical power in acute respiratory distress syndrome: opposing effects in pressure-controlled and volume-controlled ventilation modes.Frontiers in medicine · 2026Article
- Mechanical Power: Using Ideal Body Weight to Identify Injurious Mechanical Ventilation Thresholds.Respiratory care · 2025Review
- Fluid management strategies in critically ill patients with ARDS: a narrative review.European journal of medical research · 2025Review
- Comparing the impact of targeting limited driving pressure to low tidal volume ventilation on mortality in mechanically ventilated adults with COVID-19 ARDS: an exploratory target trial emulation.BMJ open respiratory research · 2024Article
- Mechanical power ratio threshold for ventilator-induced lung injury.Intensive care medicine experimental · 2024Article
- How to Prevent Ventilator-Induced Lung Injury in Intraoperative Mechanical Ventilation? A Randomized Prospective Study.Turkish journal of anaesthesiology and reanimation · 2024Article
- Evaluation of Optimal Esophageal Catheter Balloon Inflation Volume in Mechanically Ventilated Children.Respiratory care · 2024Article
- Mechanical power and normalized mechanical power in pediatric acute respiratory distress syndrome.Frontiers in pediatrics · 2024Article
- The effect of inspiratory rise time on mechanical power calculations in pressure control ventilation: dynamic approach.Intensive care medicine experimental · 2023Article
- Acute Respiratory Distress Syndrome, Mechanical Ventilation, and Inhalation Injury in Burn Patients.The Surgical clinics of North America · 2023Review
- Mechanical power is associated with weaning outcome in critically ill mechanically ventilated patients.Scientific reports · 2022Article
- Ventilation-Induced Lung Injury (VILI) in Neonates: Evidence-Based Concepts and Lung-Protective Strategies.Journal of clinical medicine · 2022Review
- Interpretation and use of intraoperative protective ventilation parameters: a scoping review.Anaesthesiology intensive therapy · 2022Article
- High Expression of CXCL10/CXCR3 in Ventilator-Induced Lung Injury Caused by High Mechanical Power.BioMed research international · 2022Article
- Miniaturization of Respiratory Measurement System in Artificial Ventilator for Small Animal Experiments to Reduce Dead Space and Its Application to Lung Elasticity Evaluation.Sensors (Basel, Switzerland) · 2021Article
- Differential Pressure Spirometry for Mechanical Ventilation Using Dichotomic Search.IEEE transactions on instrumentation and measurement · 2021Article
- The role of host defences in Covid 19 and treatments thereof.Molecular medicine (Cambridge, Mass.) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our current understanding of protective measures for avoiding ventilator-induced lung injury (VILI) has evolved from targeting low tidal volumes to lowering plateau and driving pressure. Even when pressures across the lung are reliably estimated, however, pressures alone cannot accurately gauge the injury risk; apart from flow rate, inspired oxygen fraction, and currently unmeasurable features of the mechanical microenvironment such as geometry, structural fragility, and vascular perfusion, the frequency with which high-risk tidal cycles are applied must help determine the intensity of potentially damaging energy application. Recognition of a strain threshold for damage by transpulmonary pressure, coupled with considerations of total energy load and strain intensity, has helped shape the unifying concept of VILI generation dependent upon the power transferred from the ventilator to the injured lungs. Currently, under-recognized contributors to the injury process must be addressed to minimize the risk imposed by ventilatory support.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.