Evidence map›Paper›PMID 31200487›Full record

ReviewInternational journal of molecular sciences2019

Dysregulated Transcriptional Control in Prostate Cancer.

Simon J Baumgart, Ekaterina Nevedomskaya, Bernard Haendler

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Super-enhancers complexes zoom in transcription in cancer.Journal of experimental & clinical cancer research : CR · 2023
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. GZ17-6.02 kills prostate cancer cellsFrontiers in oncology · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Targeting DNA Damage Response in Prostate and Breast Cancer.International journal of molecular sciences · 2020
    Review
  16. Review
  17. Article
  18. Advances of Zinc Signaling Studies in Prostate Cancer.International journal of molecular sciences · 2020
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Simon J BaumgartResearch & Development, Pharmaceuticals, Bayer AG, Müllerstr. 178, 13353 Berlin, Germany. simon.baumgart@bayer.com.
Ekaterina NevedomskayaResearch & Development, Pharmaceuticals, Bayer AG, Müllerstr. 178, 13353 Berlin, Germany. ekaterina.nevedomskaya@bayer.com.
Bernard HaendlerResearch & Development, Pharmaceuticals, Bayer AG, Müllerstr. 178, 13353 Berlin, Germany. bernard.haendler@bayer.com.ORCID 0000-0002-4490-0663
Bayer (Germany) · DE

Funding

Bayer Authors are employees of Bayer AG
6 · The paper itself

Abstract

Recent advances in whole-genome and transcriptome sequencing of prostate cancer at different stages indicate that a large number of mutations found in tumors are present in non-protein coding regions of the genome and lead to dysregulated gene expression. Single nucleotide variations and small mutations affecting the recruitment of transcription factor complexes to DNA regulatory elements are observed in an increasing number of cases. Genomic rearrangements may position coding regions under the novel control of regulatory elements, as exemplified by the

Indexed as

Gene Expression Regulation, NeoplasticTranscriptional ActivationAnimalsEnhancer Elements, GeneticHumansMalePromoter Regions, GeneticProstatic Neoplasmsenhancer RNAgene transcriptionprostate cancersingle-nucleotide polymorphismsuper-enhancer

Identifiers

PMID31200487
PMCPMC6627928
OpenAlexW2949378825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.