Evidence map›Paper›PMID 31200279›Full record

ReviewDrug and alcohol dependence2019

The rise of e-cigarettes, pod mod devices, and JUUL among youth: Factors influencing use, health implications, and downstream effects.

Matthew C Fadus, Tracy T Smith, Lindsay M Squeglia

Registry-linked trialAbstract readReview
In one paragraph

Review in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06335329 (Point-of-Care Ultrasound Findings and Impact on Vaping Behaviors in Adolescents), which is not on this map. Cited by 236 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
236citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06335329 nacompletednot on this mapstarted 2024, after this paper: background citation

Point-of-Care Ultrasound Findings and Impact on Vaping Behaviors in Adolescents

TypeinterventionalSponsorMedical University of South CarolinaRan2024 to 2026Enrolled90ConditionsVapingArmsDiscussion of point-of-care ultrasound lung findings
3 · Its place in the literature

Who cites it

236 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Trial
  11. Abuse Liability of Electronic Cigarettes in Never-Smoking Electronic Cigarette Users.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Trial
  12. Trial
  13. Article
  14. Review
  15. Article
  16. Article
  17. The role of peer influence in shaping developmental trajectories of substance use expectancies in early adolescence.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026
    Article
  18. Review
  19. Article
  20. Article

176 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matthew C FadusDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC, 29425, USA. Electronic address: fadus@musc.edu.
Tracy T SmithDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC, 29425, USA.
Lindsay M SquegliaDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC, 29425, USA.

Funding

13/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT MUSCU01DA041093 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Kevin M. Gray, Lindsay Squeglia · 2017 to 2026
$10.7M
Drug Abuse Research Training (DART) ProgramR25DA020537 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KATHLEEN T. BRADY, Sudie E Back · 2006 to 2026
$6.3M
A Proof-of-Concept Trial of N-Acetylcysteine for Adolescent Alcohol Use DisorderR01AA027399 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GRAY, KEVIN M, SQUEGLIA, LINDSAY · 2018 to 2022
$3.5M
Neuroscience-informed Treatment Development for Adolescent Alcohol Use DisordersK23AA025399 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SQUEGLIA, LINDSAY · 2016 to 2020
$1.0M
Impact of e-cigarette characteristics on reinforcement and tobacco use patterns among current smokersK01DA047433 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SMITH, TRACY TAYLOR · 2019 to 2023
$988k
NIAAA NIH HHS K23 AA025399NIAAA NIH HHS R01 AA027399NIDA NIH HHS K01 DA047433NIDA NIH HHS R25 DA020537NIDA NIH HHS U01 DA041093
6 · The paper itself

Abstract

backgroundElectronic cigarettes (e-cigarettes) were first introduced in the U.S. market in 2006, with the more recent evolution of "pod-mod" e-cigarettes such as JUUL introduced in 2015. Although marketed as a smoking cessation tool, e-cigarettes are rarely used for this purpose in youth. This review aims to synthesize the literature regarding e-cigarette use among youth, and provides a resource for clinicians, educators, and families that helps answer commonly asked questions about e-cigarettes.

methodsPubMed, Scopus, and PsycINFO search was performed using search terms "Electronic Nicotine Delivery Systems," "e cigarettes," "e-cigarettes," "electronic cigarettes," "vaping," "JUUL," "e-cigs," and "vape pens." Search results were filtered to only include those related to adolescents and young adults.

resultsE-cigarette use among youth is common, with rates of use increasing from 1.5% in 2011 to 20.8% in 2018. Pod mod devices such as JUUL have gained favor among youth for their sleek design, user-friendly function, desirable flavors, and ability to be used discreetly in places where smoking is forbidden. Adolescents are often uninformed about the constituents of e-cigarettes, and little is known about the long-term effects of e-cigarettes. Studies have suggested a "gateway" effect for combustible cigarettes and cannabis use.

conclusionsE-cigarette use is becoming increasingly common among youth, leading to a myriad of questions and concerns from providers, educators, and family members. More research is needed to determine the ultimate public health impact of e-cigarette use. The authors provide a summary table of frequently asked questions in order to help clarify these common concerns.

Indexed as

AdolescentAdultAge FactorsElectronic Nicotine Delivery SystemsFemaleFlavoring AgentsHumansMaleSmokingSmoking CessationSocioeconomic FactorsVapingYoung AdultFlavoring AgentsAdolescentE-cigaretteJUULNicotinePod modYouth

Identifiers

PMID31200279
PMCPMC7183384

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.