Evidence map›Paper›PMID 31200239›Full record

ArticleRedox biology2019

L-NAME releases nitric oxide and potentiates subsequent nitroglycerin-mediated vasodilation.

Taiming Liu, Meijuan Zhang, George T Mukosera, Dan Borchardt, Qian Li, Trent E Tipple, Abu Shufian Ishtiaq Ahmed, Gordon G Power, Arlin B Blood

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
  2. Article
  3. Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Effects of Nitric Oxide Expression on Hearing Loss.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Article
  10. Microfluidic Modulation of Microvasculature in Microdissected Tumors.bioRxiv : the preprint server for biology · 2024
    Article
  11. Review
  12. HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  13. Article
  14. Fluorescent small molecule donors.Chemical Society reviews · 2024
    Review
  15. Article
  16. Article
  17. Profiling the Phytochemicals ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  18. Article
  19. Anti-Inflammatory Activity ofPharmaceuticals (Basel, Switzerland) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Taiming LiuDepartment of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA.
Meijuan ZhangDepartment of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA.
George T MukoseraDepartment of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA.
Dan BorchardtDepartment of Chemistry, University of California, Riverside, CA, 92521, USA.
Qian LiNeonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Trent E TippleNeonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Abu Shufian Ishtiaq AhmedCenter for Dental Research, Loma Linda University School of Dentistry, Loma Linda, CA, 92350, USA.
Gordon G PowerLawrence D. Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA.
Arlin B BloodDepartment of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA; Lawrence D. Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA. Electronic address: ablood@llu.edu.
Loma Linda University · USUniversity of Alabama at Birmingham · USUniversity of California, Riverside · US

Funding

Uterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI DUCSAY, CHARLES A · 2016 to 2020
$6.3M
Targeting Thioredoxin Reductase-1 to Prevent Bronchopulmonary DysplasiaR01HL119280 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TIPPLE, TRENT · 2014 to 2018
$2.0M
NHLBI NIH HHS R01 HL119280NICHD NIH HHS P01 HD083132
6 · The paper itself

Abstract

L-N

Indexed as

AnimalsArginineEnzyme InhibitorsFemaleMesenteric ArteriesMiceMyographyNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseNitroglycerinomega-N-MethylarginineRatsRats, Sprague-DawleyRAW 264.7 CellsReactive Oxygen SpeciesArginineEnzyme InhibitorsNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseNitroglycerinomega-N-MethylarginineReactive Oxygen SpeciesVasodilator AgentsFenton chemistryL-arginine analoguesL-NAMENitrodilatorPreformed intracellular NO store

Identifiers

PMID31200239
PMCPMC6565607
OpenAlexW2948290726

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.