Evidence map›Paper›PMID 31200187›Full record

ReviewCurrent opinion in immunology2019

Reactive nitrogen species in host-bacterial interactions.

Ferric C Fang, Andrés Vázquez-Torres

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Oxidative stress inducesMicrobiology spectrum · 2026
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  7. Review
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  13. Flow cytometry study ofFrontiers in microbiology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ferric C FangDepartment of Microbiology, University of Washington School of Medicine, Seattle, WA 98195-7735, USA; Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195-7110, USA. Electronic address: fcfang@uw.edu.
Andrés Vázquez-TorresDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA; Veterans Affairs Eastern Colorado Health Care System, Denver, CO 80220, USA.

Funding

Salmonella evasion of NADPH oxidase-dependent killingR01AI054959 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAZQUEZ-TORRES, ANDRES · 2003 to 2018
$5.2M
Molecular determinants of oxidative stress in Salmonella pathogenesisR01AI136520 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Andres Vazquez-Torres · 2018 to 2026
$3.7M
Typhoid Pathogenesis and ImmunityR01AI112640 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2015 to 2019
$2.1M
Antimicrobial Actions of Nitric OxideR01AI118962 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2016 to 2020
$1.9M
Regulation of S. aureus Colonization by NO.R01AI123124 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2016 to 2020
$1.9M
Typhoid Pathogenesis and ImmunityR56AI112640 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2020 to 2020
$574k
Analysis of intracellular host defenses in Salmonella pathogenesisR56AI054959 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAZQUEZ-TORRES, ANDRES · 2008 to 2008
$378k
Molecular Analysis of Bacterial Adaptive Response to Host Reactive SpeciesI01BX002073 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI Andres Vazquez-Torres · 2013 to 2026
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BLRD VA I01 BX002073NIAID NIH HHS R01 AI054959NIAID NIH HHS R01 AI112640NIAID NIH HHS R01 AI118962NIAID NIH HHS R01 AI123124NIAID NIH HHS R01 AI136520NIAID NIH HHS R56 AI054959NIAID NIH HHS R56 AI112640
6 · The paper itself

Abstract

Reactive nitrogen species play diverse and essential roles in host-pathogen interactions. Here, we review selected recent discoveries regarding nitric oxide (NO) in host defense and the pathogenesis of infection, mechanisms of bacterial NO resistance, production of NO by human macrophages, NO-based antimicrobial therapeutics and NO interactions with the gut microbiota.

Indexed as

Bacterial Physiological PhenomenaHost-Pathogen InteractionsAnimalsBacterial InfectionsDisease ResistanceGastrointestinal MicrobiomeHumansMacrophagesReactive Nitrogen SpeciesReactive Nitrogen Species

Identifiers

PMID31200187
PMCPMC6800629

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.