Evidence map›Paper›PMID 31200153›Full record

ArticleEnvironment international2019

County-level radon exposure and all-cause mortality risk among Medicare beneficiaries.

Maayan Yitshak-Sade, Annelise J Blomberg, Antonella Zanobetti, Joel D Schwartz, Brent A Coull, Itai Kloog, Francesca Dominici, Petros Koutrakis

Open access · goldAbstract read
In one paragraph

Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. High-resolution national radon maps based on massive indoor measurements in the United States.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Radon Biomonitoring and microRNA in Lung Cancer.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Maayan Yitshak-SadeExposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: myitshak@hsph.harvard.edu.
Annelise J BlombergExposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Antonella ZanobettiExposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Joel D SchwartzExposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Brent A CoullExposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Itai KloogDepartment of Geography and Environmental Development, Faculty of Humanities and Social Sciences, Ben-Gurion University, Beer-Sheva, Israel.
Francesca DominiciExposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Petros KoutrakisExposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USBen-Gurion University of the Negev · IL

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Marc G Weisskopf · 1985 to 2026
$44.6M
COPD and Response to Traffic Related ParticlesR01ES019853 · NIEHS · HARVARD MEDICAL SCHOOL · PI GARSHICK, ERIC · 2012 to 2016
$3.1M
Cardiovascular Health and Air Pollution: A National StudyR01ES024332 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI ZANOBETTI, ANTONELLA · 2015 to 2018
$2.5M
Transporting established insights from classical experimental design to address causal questions in environmental epidemiology including the understanding of biological mediating mechanismsDP5OD021412 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BIND, MARIE-ABELE CATHERINE · 2016 to 2020
$2.1M
EPA R835872NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES019853NIEHS NIH HHS R01 ES024332NIH HHS DP5 OD021412ODCDC CDC HHS DP5 OD021412
6 · The paper itself

Abstract

backgroundRadon is an inert gas formed from the decay of naturally-occurring materials in the earth's crust. It infiltrates into homes from soil, water, and construction materials. Its decay products are radionuclides, which attach to ambient particles. Residential radon is one of the leading risk factors for lung cancer. The scarce evidence for associations with other mortality causes originates mostly from occupational studies.

methodsIn a cohort study with 14 years of follow-up (2000-2013), we evaluated the association between chronic radon exposure and all-cause mortality, and explored whether there are subpopulations who are more vulnerable to radon effects. We included 87,296,195 person-years of follow-up from all Medicare beneficiaries in the Mid-Atlantic and Northeastern U.S. states. We examined the association between the logarithm of county-averaged radon (ln(Rn)) and mortality and assessed effect modification by chronic conditions.

resultsAn interquartile range increase in the ln(Rn) was associated with a 2·62% increase (95% CI 2·52%; 2·73%) in mortality, independent of PM

conclusionWe found an increased risk for all-cause mortality associated with increased radon exposure. The risk was enhanced among susceptible individuals with chronic conditions. We believe this is the first cohort study to identify populations at higher risk for non-malignant health consequences of radon exposure. Due to the limitations in exposure assessment and availability of individual confounders, these findings should be interpreted with caution.

Indexed as

MortalityAgedAged, 80 and overAir Pollutants, RadioactiveCohort StudiesFemaleHumansMaleMedicareRadiation ExposureRadiation MonitoringRadonRisk FactorsUnited StatesAir Pollutants, RadioactiveRadonMortalityPM(2.5)RadiationRadon

Identifiers

PMID31200153
PMCPMC6679989
OpenAlexW2952350976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.