ArticleCortex; a journal devoted to the study of the nervous system and behavior2019
Affective reactivity during adolescence: Associations with age, puberty and testosterone.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Effects of sex, pubertal stage, and pubertal hormones on frontal and limbic responses to fearful and happy faces during early adolescence.Psychoneuroendocrinology · 2026Article
- Normative scores and clinical cut-offs of the Cyclothymic-Hypersensitive Temperament Questionnaire in adolescence.JCPP advances · 2026Article
- Changes in emotional granularity under a population-level stressor predict social anxiety and depressive symptoms.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.Human brain mapping · 2026Article
- Sex and age differences on how testosterone relates to brain activity during working memory among adolescents and young adults.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Developmental shifts in testosterone levels are associated with alterations in the neural oscillatory dynamics serving selective attention.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The Development of Ambiguity Processing Is Explained by an Inverted U-Shaped Curve.Behavioral sciences (Basel, Switzerland) · 2024Article
- Comparing the multivariate relationships of conceptual adversity models and structural brain development in adolescent girls: A registered report.Developmental psychology · 2024Article
- Behavioral and neural responses to social rejection: Individual differences in developmental trajectories across childhood and adolescence.Developmental cognitive neuroscience · 2024Article
- Exposure to community violence as a mechanism linking neighborhood disadvantage to amygdala reactivity and the protective role of parental nurturance.Developmental psychology · 2024Article
- Developmental changes in endogenous testosterone have sexually-dimorphic effects on spontaneous cortical dynamics.Human brain mapping · 2023Article
- The role of puberty on physical and brain development: A longitudinal study in male Rhesus Macaques.Developmental cognitive neuroscience · 2023Article
- Sex and pubertal influences on the neurodevelopmental underpinnings of schizophrenia: A case for longitudinal research on adolescents.Schizophrenia research · 2023Review
- Immature excitatory neurons in the amygdala come of age during puberty.Developmental cognitive neuroscience · 2022Article
- Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior.Social cognitive and affective neuroscience · 2022Article
- Age-related change in task-evoked amygdala-prefrontal circuitry: A multiverse approach with an accelerated longitudinal cohort aged 4-22 years.Human brain mapping · 2022Article
- Age- and sex-based differences in the moral intuitions of American early adolescents.Evolutionary human sciences · 2022Article
- Raging Hormones: Why Age-Based Etiological Conceptualizations of the Development of Antisocial Behavior Are Insufficient.Frontiers in behavioral neuroscience · 2022Review
- Affective Development from Middle Childhood to Late Adolescence: Trajectories of Mean-Level Change in Negative and Positive Affect.Journal of youth and adolescence · 2021Article
- Exploring valence bias as a metric for frontoamygdalar connectivity and depressive symptoms in childhood.Developmental psychobiology · 2021Article
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Authors and funding
5 authors.
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Abstract
Adolescence is a period of heightened social engagement that is accompanied by normative changes in neural reactivity to affective stimuli. It is also a period of concurrent endocrine and physical changes associated with puberty. A growing body of research suggests that hormonal shifts during adolescence impact brain development, but minimal research in humans has examined the relationship between intra-individual changes in puberty and brain function. The current study examines linear and nonlinear changes in affective reactivity in a longitudinal sample of 82 adolescents who underwent three fMRI sessions between the ages of 9 and 18 years. Changes in response to affective facial stimuli were related to age, pubertal stage, and testosterone levels. Using multilevel modeling, we highlight extensive nonlinear development of socio-emotional responsivity across the brain. Results include mid-pubertal peaks in amygdala and hippocampus response to fearful expressions, as well as sex differences in regions subserving social and self-evaluative processes. However, testosterone levels exhibited inverse patterns of association with neural response compared to pubertal stage in females (e.g., U-shaped relationship with the amygdala and hippocampus). Findings highlight potentially unique roles of age, pubertal stage and testosterone on socio-emotional development during adolescence, as well as sex differences in these associations.
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