Evidence map›Paper›PMID 31199605›Full record

ArticleArthritis care & research2020

Relation of Patellofemoral Joint Alignment, Morphology, and Radiographic Osteoarthritis to Frequent Anterior Knee Pain: Data from the Multicenter Osteoarthritis Study.

Erin M Macri, Tuhina Neogi, Irina Tolstykh, Rafael Widjajahakim, Cora E Lewis, James C Torner, Michael C Nevitt, Michael Roux, Joshua J Stefanik

Open access · greenAbstract readEvaluation StudyMulticenter Study
In one paragraph

Article in Arthritis care & research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

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  16. Usefulness of three-dimensional computed tomography for patellofemoral measurement.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Erin M MacriUniversity of Delaware, Newark, and Erasmus MC, Rotterdam, The Netherlands.ORCID 0000-0003-2798-6052
Tuhina NeogiSchool of Medicine, Boston University, Boston, Massachusetts.
Irina TolstykhUniversity of California, San Francisco.
Rafael WidjajahakimUniversity of Massachusetts Medical School, Worcester.ORCID 0000-0002-9050-9454
Cora E LewisUniversity of Alabama, Birmingham.
James C TornerUniversity of Iowa, Iowa City.
Michael C NevittUniversity of California, San Francisco.
Michael RouxHospital for Special Surgery, New York, New York.
Joshua J StefanikUniversity of Delaware, Newark, and School of Medicine, Boston University and Northeastern University, Boston, Massachusetts.
Boston University · USUniversity of California, San Francisco · USErasmus MC · NLHospital for Special Surgery · USUniversity of Alabama at Birmingham · USUniversity of Iowa · USUniversity of Massachusetts Chan Medical School · US

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Susan Poland Giancola · 2013 to 2026
$60.5M
Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7M
WORK DISABILITY-- PERSONS WITH RHEUMATOID ARTHRITISP60AR047785 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2016
$18.0M
Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1M
Multicenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6M
Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2M
Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Michael Paul Lavalley · 2019 to 2026
$6.9M
UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2014 to 2018
$3.0M
Central Sensitization in Post-Knee Replacement Pain and Relation to OA PathologyR01AR062506 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NEOGI, TUHINA · 2012 to 2016
$2.4M
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1M
The Relation of Altered Pain Processing to Impact Loading and Response to a Gait Retraining Treatment in Knee OsteoarthritisK23AR070913 · NIAMS · UNIVERSITY OF DELAWARE · PI STEFANIK, JOSHUA JON · 2017 to 2021
$828k
NIAMS NIH HHS K23 AR070913NIAMS NIH HHS K24 AR070892NIAMS NIH HHS P30 AR066262NIAMS NIH HHS P30 AR072571NIAMS NIH HHS P60 AR047785NIAMS NIH HHS R01 AR062506NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

objectivePatellofemoral (PF) alignment and trochlear morphology are associated with PF osteoarthritis (OA) and knee pain, but whether they are associated with localized anterior knee pain is unknown, which is believed to be a symptom specific to PF joint pathology. We therefore aimed to evaluate the relation of PF alignment and morphology, as well as PFOA and tibiofemoral OA, to anterior knee pain.

methodsThe Multicenter Osteoarthritis Study is a cohort study of individuals with, or at risk for, knee OA. We evaluated cross-sectional associations of PF alignment, trochlear morphology, and PF and tibiofemoral radiographic OA, with localized anterior knee pain (defined with a pain map). We used 2 approaches: a within-person knee-matched evaluation of participants with unilateral anterior knee pain (conditional logistic regression), and a cohort approach comparing those with anterior knee pain to those without (binomial regression).

resultsWith the within-person knee-matched approach (n = 110; 64% women, mean age 70 years, body mass index [BMI] 30.9), PF alignment, morphology, and tibiofemoral OA were not associated with unilateral anterior knee pain. Radiographic PFOA was associated with pain, odds ratio 5.3 (95% confidence interval [95% CI] 1.6-18.3). Using the cohort approach (n = 1,818; 7% of knees with anterior knee pain, 59% women, mean age 68 years, BMI 30.4), results were similar: only PFOA was associated with pain, with a prevalence ratio of 2.2 (95% CI 1.4-3.4).

conclusionPF alignment and trochlear morphology were not associated with anterior knee pain in individuals with, or at risk for, knee OA. Radiographic PFOA, however, was associated with pain, suggesting that features of OA, more so than mechanical features, may contribute to localized symptoms.

Indexed as

RadiographyAgedArthralgiaCohort StudiesCross-Sectional StudiesFemaleHumansKnee JointLogistic ModelsMaleMiddle AgedOdds RatioOsteoarthritis, KneePain MeasurementPatellofemoral JointRange of Motion, Articular

Identifiers

PMID31199605
PMCPMC6911012
OpenAlexW2952058006

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.