ArticleCancer medicine2019
Spatial distribution characteristics of tumor marker CA724 reference values in China.
Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Identification and Validation of Biomarkers to Predict Early Diagnosis of Inflammatory Bowel Disease and Its Progression to Colorectal Cancer.Biochemical genetics · 2025Article
- Enhancing T-cell response with monoclonal antibodies and chemotherapy in advanced gastric cancer.World journal of gastrointestinal oncology · 2025Article
- Environment-Associated Variations in Blood Metabolism of Mongolian Cattle Grazing in the Alxa Desert of China.Veterinary sciences · 2025Article
- Impact of oxaliplatin and trastuzumab combination therapy on tumor markers and T lymphocyte subsets for advanced gastric cancer.World journal of gastrointestinal oncology · 2024Article
- Development of a clinical nomogram for prediction of response to neoadjuvant chemotherapy in patients with advanced gastric cancer.World journal of gastrointestinal surgery · 2024Article
- Determination of serum CA724 levels using fluorescence immunochromatography.BMC biotechnology · 2023Article
- Predictive modeling the probability of suffering from metabolic syndrome using machine learning: A population-based study.Heliyon · 2022Article
- Association of multiple tumor markers with newly diagnosed gastric cancer patients: a retrospective study.PeerJ · 2022Article
- Prevalence and spatial distribution characteristics of human echinococcosis in China.PLoS neglected tropical diseases · 2021Article
- Status quo and future prospects of artificial neural network from the perspective of gastroenterologists.World journal of gastroenterology · 2021Review
- CA724 predicts overall survival in locally advanced gastric cancer patients with neoadjuvant chemotherapy.BMC cancer · 2021Article
- Elevated carbohydrate antigen 125 post-operation as a prognostic marker in gastric cancer patients with stage II-III.Translational cancer research · 2020Article
- Spatial distribution characteristics of tumor marker CA724 reference values in China.Cancer medicine · 2019Article
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Authors and funding
4 authors.
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Abstract
objectsThis study aims to explore the Cancer antigen 724 (CA724) reference values spatial distribution characteristics in healthy Chinese adults. The study can provide regional reference for medical diagnosis. STUDY
designThe relationship between CA724 and 25 geographical environmental factors was analyzed firstly. Artificial neural network simulation training was used to construct the prediction model. The national forecast distribution map of the CA724 reference values was obtained by the geostatistical mapping method. Analyzing and exploring the influence mechanism of geographical environment factors on CA724 reference values.
methodsCollecting 34470 cases from more than 106 cities healthy adults CA724 reference values via several paper databases in 10 recent years. Correlation analysis, RBF artificial neural networks and trend surface analysis were applied to explore if there was any tendency of spatial variation. The Kriging interpolation of geostatistical analysis was developed to reveal the spatial distribution characteristics of the CA724 reference values.
resultsThe distribution of CA724 reference values of Chinese healthy adults shows a downward trend from south to north. CA724 reference values have negative correlations with latitude, annual sunshine duration and topsoil cation exchange capacity in clay. CA724 have positive correlations with annual mean air temperature, annual mean relative humidity, and annual precipitation amount. High temperature and high humidity environment will reduce gastrointestinal function and breeze various mold bacteria. Lack of sunshine can easily lead to vitamin C deficiency in the body. These will increase the incidence of gastrointestinal diseases and gastric cancer, then increase the CA724 value.
conclusionCA724 reference values show spatial autocorrelation and regional variation. There are some geographical environment factors effected Chinese healthy adults CA724 reference values. Geographic factors such as sunshine, temperature, and humidity have effects on CA724 reference values can provide new ideas and directions of prevention and clinical diagnosis in the future.
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