Observational studyRheumatology (Oxford, England)2019
Subglottic stenosis and endobronchial disease in granulomatosis with polyangiitis.
Observational study in Rheumatology (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- The 2025 British Society for Rheumatology management recommendations for ANCA-associated vasculitis.Rheumatology (Oxford, England) · 2025Guideline
- Ear-nose-throat manifestations of granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis: a cross-sectional study.Rheumatology international · 2026Article
- Systemic Immunosuppression to Reduce Surgical Intervention in ANCA-Negative Subglottic Stenosis.The Laryngoscope · 2026Article
- Infracordal Stenosis: A Glucocorticoid-Responsive Subtype of Autoimmune Laryngotracheal Stenosis.The Laryngoscope · 2026Article
- Immunosuppression and Surgery-Free Interval in Granulomatosis With Polyangiitis Airway Stenosis.The Laryngoscope · 2026Article
- Tracheobronchial Stenosis in Granulomatosis With Polyangiitis: Immunosuppressant Use and Airway Dilation Frequency.ACR open rheumatology · 2026Article
- C-Reactive Protein Serum Values in Idiopathic and Autoimmune Subglottic Stenosis.The Laryngoscope · 2026Article
- The Impact of Estrogen on Stromal Elements in the Proximal Airway in Idiopathic Subglottic Stenosis.The Laryngoscope · 2026Article
- "We were already there where the narrow path …" Benign tracheal stenosis treatment: narrative review on the state of the art and future direction.Updates in surgery · 2026Review
- Benign subglottic stenosis from a rheumatologist' perspective: a narrative review.Clinical rheumatology · 2025Review
- A closer look to the lung involvement in ANCA-associated vasculitis: alveolar haemorrhage and interstitial lung disease.Clinical and experimental medicine · 2025Article
- Association between anxiety and depression and sleep quality in benign laryngotracheal stenosis patients and analysis of risk factors.World journal of psychiatry · 2025Article
- Partial cricotracheal resection for treatment of subglottic stenosis: complications and outcomes.Frontiers in surgery · 2025Article
- Distribution of Airway Findings in ANCA-Associated Vasculitis: A 20-Year Observational Analysis.Diagnostics (Basel, Switzerland) · 2024Article
- A life-threatening manifestation of granulomatosis with polyangiitis: Subglottic stenosis.Archives of rheumatology · 2024Article
- Article
- Prevalence and characteristics of bronchiectasis in ANCA-associated vasculitis: A systematic review and meta-analysis.Archives of rheumatology · 2024Review
- Similarity Network Analysis of the Adaptive Immune Response in the Proximal Airway.The Laryngoscope · 2024Article
- Pulmonary function in patients with ANCA-associated vasculitis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2024Article
- Characterizing the T Cell Repertoire in the Proximal Airway in Health and Disease.The Laryngoscope · 2024Article
Corrections and comments
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Authors and funding
21 authors at 14 institutions in 2 countries.
Funding
Abstract
objectivesTo describe tracheobronchial disease in patients with granulomatosis with polyangiitis (GPA) and evaluate the utility of dynamic expiratory CT to detect large-airway disease.
methodsDemographic and clinical features associated with the presence of subglottic stenosis (SGS) or endobronchial involvement were assessed in a multicentre, observational cohort of patients with GPA. A subset of patients with GPA from a single-centre cohort underwent dynamic chest CT to evaluate the airways.
resultsAmong 962 patients with GPA, SGS and endobronchial disease were identified in 95 (10%) and 59 (6%) patients, respectively. Patients with SGS were more likely to be female (72% vs 53%, P < 0.01), younger at time of diagnosis (36 vs 49 years, P < 0.01), and have saddle-nose deformities (28% vs 10%, P < 0.01), but were less likely to have renal involvement (39% vs 62%, P < 0.01). Patients with endobronchial disease were more likely to be PR3-ANCA positive (85% vs 66%, P < 0.01), with more ENT involvement (97% vs 77%, P < 0.01) and less renal involvement (42% vs 62%, P < 0.01). Disease activity in patients with large-airway disease was commonly isolated to the subglottis/upper airway (57%) or bronchi (32%). Seven of 23 patients screened by dynamic chest CT had large-airway pathology, including four patients with chronic, unexplained cough, discovered to have tracheobronchomalacia.
conclusionSGS and endobronchial disease occur in 10% and 6% of patients with GPA, respectively, and may occur without disease activity in other organs. Dynamic expiratory chest CT is a potential non-invasive screening test for large-airway involvement in GPA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.