ReviewIntegrative and comparative biology2019
Integration and the Developmental Genetics of Allometry.
Review in Integrative and comparative biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Shared genetic basis and structure of syndromic and normal facial variation.American journal of human genetics · 2026Article
- Scaling law links plant growth variation to grain yield in wheat stands.The New phytologist · 2026Article
- Structural Equation Modeling Reveals How Allometry Shapes Integration in Avian Cranial Evolution.Integrative and comparative biology · 2026Article
- Femur Shape Changes in Prg4-Deficient Mice: Morphological Insights Into Joint Well-Being.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Ecomorphological Analysis of the Bird Lumbosacral Organ in an Evolutionary Context.Journal of morphology · 2025Article
- Integration of postnatal craniofacial development and the effects of diet consistency in rodents.Proceedings. Biological sciences · 2025Article
- Endocranial shape variation and allometry in Euarchontoglires.Scientific reports · 2024Article
- Genetic and environmental effects on morphological traits of social phenotypes in wasps.Heredity · 2024Article
- Bayesian Total-Evidence Dating Revisits Sloth Phylogeny and Biogeography: A Cautionary Tale on Morphological Clock Analyses.Systematic biology · 2024Article
- Diversity in the internal functional feeding elements of sympatric morphs of Arctic charr (Salvelinus alpinus).PloS one · 2024Article
- Conical and sabertoothed cats as an exception to craniofacial evolutionary allometry.Scientific reports · 2023Article
- The genetic basis of neurocranial size and shape across varied lab mouse populations.Journal of anatomy · 2022Article
- Flexible conservatism in the skull modularity of convergently evolved myrmecophagous placental mammals.BMC ecology and evolution · 2022Article
- Article
- MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses.Scientific data · 2022Article
- Article
- A ROR2 coding variant is associated with craniofacial variation in domestic pigeons.Current biology : CB · 2021Article
- Complex genetic architecture of three-dimensional craniofacial shape variation in domestic pigeons.Evolution & development · 2021Article
- What constrains adaptive radiation? Documentation and explanation of under-evolved morphologies inProceedings. Biological sciences · 2021Article
- Genetic Association Analysis for Relative Growths of Body Compositions and Metabolic Traits to Body Weights in Broilers.Animals : an open access journal from MDPI · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Allometry refers to the ways in which organismal shape is associated with size. It is a special case of integration, or the tendency for traits to covary, in that variation in size is ubiquitous and evolutionarily important. Allometric variation is so commonly observed that it is routinely removed from morphometric analyses or invoked as an explanation for evolutionary change. In this case, familiarity is mistaken for understanding because rarely do we know the mechanisms by which shape correlates with size or understand their significance. As with other forms of integration, allometric variation is generated by variation in developmental processes that affect multiple traits, resulting in patterns of covariation. Given this perspective, we can dissect the genetic and developmental determinants of allometric variation. Our work on the developmental and genetic basis for allometric variation in craniofacial shape in mice and humans has revealed that allometric variation is highly polygenic. Different measures of size are associated with distinct but overlapping patterns of allometric variation. These patterns converge in part on a common genetic basis. Finally, environmental modulation of size often generates variation along allometric trajectories, but the timing of genetic and environmental perturbations can produce deviations from allometric patterns when traits are differentially sensitive over developmental time. These results question the validity of viewing allometry as a singular phenomenon distinct from morphological integration more generally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.